Serum beta2-microglobulin concentration as a novel marker to distinguish levels of risk in acute heart failure patients
| Autor: | Ken-ichi Hirata, Keisuke Kawai, Toshiyuki Miyazaki, Eiichi Tajiri, Masuki Mori, Seinosuke Kawashima, Tetsuya Inatome, Kazuhisa Kitazaki, Hiroshi Yamabe, Mitsuhiro Yokoyama, Tomohiko Shirotani |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Nedocromil medicine.medical_specialty Renal function Blood Pressure Body Mass Index Sudden cardiac death Pulmonary Disease Chronic Obstructive chemistry.chemical_compound Recurrence Internal medicine medicine Humans Mortality Outcome Aged Heart Failure Creatinine Beta-2 microglobulin business.industry Prognosis medicine.disease Blood pressure chemistry Echocardiography Heart failure Cardiology Female beta 2-Microglobulin business Cardiology and Cardiovascular Medicine Body mass index Biomarkers Predictor Glomerular Filtration Rate medicine.drug |
| Zdroj: | Journal of Cardiology. 55(1):99-107 |
| ISSN: | 0914-5087 |
| DOI: | 10.1016/j.jjcc.2009.10.003 |
| Popis: | SummaryBackgroundRecently, serum beta2-microglobulin, an endogenous marker for renal function, has been shown to be an independent predictor of mortality in older adults. However, the prognostic role of beta2-microglobulin in heart failure has not been elucidated.MethodsWe prospectively evaluated serum beta2-microglobulin and creatinine concentrations, creatinine-based renal parameters (estimated glomerular filtration rate and creatinine clearance), and echocardiographic data in 131 patients with acute heart failure and creatinine concentrations ≤3.0mg/dL admitted to our hospitals.ResultsDuring 2.3±1.3 years, 42 patients died of cardiovascular causes and 12 died of noncardiac causes. Cardiovascular events were observed in 63 patients: 53 were readmitted due to worsening heart failure, 5 readmitted for cerebral embolism, and 5 died from sudden cardiac death. According to multivariate stepwise Cox proportional hazard analysis, higher baseline serum beta2-microglobulin concentrations (X2=16, p |
| Databáze: | OpenAIRE |
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