Successive treatment with cyclosporine and infliximab in steroid-refractory ulcerative colitis
| Autor: | Leblanc, S., Allez, M., Seksik, P., Flourié, B., Peeters, H., Dupas, J. L., Bouguen, G., Peyrin-Biroulet, L., Duclos, B., Bourreille, A., Dewit, O., Bouhnik, Y., Michetti, P., Chaussade, S., Saussure, P., Mary, J. Y., Colombel, J. F., Lémann, M., Renseigné, Non |
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| Přispěvatelé: | Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Anti-Inflammatory Agents Drug Resistance Administration Oral Drug resistance Infections Gastroenterology Inflammatory bowel disease Young Adult Rescue therapy Internal medicine medicine Humans Colitis Child Colectomy Retrospective Studies Salvage Therapy Hepatology business.industry [CHIM.ORGA]Chemical Sciences/Organic chemistry Antibodies Monoclonal Retrospective cohort study Middle Aged medicine.disease Ulcerative colitis Infliximab Treatment Outcome Injections Intravenous Cyclosporine Colitis Ulcerative Female Steroids Pulmonary Embolism business Follow-Up Studies medicine.drug |
| Zdroj: | The American Journal of Gastroenterology The American Journal of Gastroenterology, 2011, 106 ((4)), pp.771-7. ⟨10.1038/ajg.2011.62⟩ |
| ISSN: | 0002-9270 1572-0241 |
| Popis: | International audience; OBJECTIVES: Rescue therapy with either cyclosporine (CYS) or infliximab (IFX) is an effective option in patients with intravenous steroid-refractory attacks of ulcerative colitis (UC). In patients who fail, colectomy is usually recommended, but a second-line rescue therapy with IFX or CYS is an alternative. The aims of this study were to investigate the efficacy and tolerance of IFX and CYS as a second-line rescue therapy in steroid-refractory UC or indeterminate colitis (IC) unsuccessfully treated with CYS or IFX. METHODS: This was a retrospective survey of patients seen during the period 2000-2008 in the GETAID centers. Inclusion criteria included a delay of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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