Clinical features of OKT4+/OKT8+ adult T-cell leukemia
| Autor: | Toshihide Unoki, Toshio Kitamura, Kazuo Tamura, Masashi Seita, Kimitaka Sagawa, Yatsuki Aratake, Sachiya Ohtaki, Nobuyoshi Tachibana, Kazunari Yamaguchi |
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| Rok vydání: | 1985 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty T-Lymphocytes T-cell leukemia chemical and pharmacologic phenomena Disease Biology Virus Antigen hemic and lymphatic diseases Coagulopathy medicine Humans Aged Deltaretrovirus Infections Antibodies Monoclonal hemic and immune systems Hematology Middle Aged Prognosis medicine.disease Phenotype Leukemia Oncology Antigens Surface DNA Viral Immunology biology.protein Female Antibody |
| Zdroj: | Leukemia Research. 9:1353-1359 |
| ISSN: | 0145-2126 |
| Popis: | Adult T-cell leukemia (ATL) has a range of clinical characteristics. Phenotypically the leukemic cells usually express the helper/inducer associated antigen OKT4 with lack of OKT8. We have observed three patients with acute ATL cytologically indistinguishable from OKT4+/OKT8- ATL but whose neoplastic cells had the unusual phenotype, OKT3+, OKT4+, OKT6-, OKT8+ OKT9+/-, OKT11+, Tac+/-, TdT-. All patients had abnormal karyotypes and antibodies against anti-ATL associated antigens as well as proviral DNA of human T-cell leukemia virus in the leukemic cells. The clinical course was complicated by skin eruptions, hypercalcemia, pulmonary infection and disseminated intravascular coagulopathy. All died of complications shortly after diagnosis. The clinical features of these patients were similar to those of OKT4+/OKT8- ATL. However, their acute course suggests that co-expression surface antigens OKT4 and OKT8 may be a sign of aggressive nature of the disease with poor prognosis. |
| Databáze: | OpenAIRE |
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