Surgical and Systemic Treatment of Hereditary Breast Cancer: A Mini-Review With a Focus on BRCA1 and BRCA2 Mutations
| Autor: | Maneesha Patwardhan, Leyla Swafe, Athanasios Pouptsis, Chara Stavraka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Younger age Mini Review medicine.disease_cause surgical management lcsh:RC254-282 Mini review 03 medical and health sciences 0302 clinical medicine Germline mutation Breast cancer breast cancer Internal medicine Medicine skin and connective tissue diseases genes Mutation business.industry systemic treatment Platinum salts medicine.disease BRCA1 lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens BRCA2 030104 developmental biology 030220 oncology & carcinogenesis Personalized medicine business hereditary Hereditary Breast Cancer |
| Zdroj: | Frontiers in Oncology, Vol 10 (2020) Frontiers in Oncology |
| Popis: | Hereditary breast cancer accounts for 5%-10% of breast cancer cases. The majority of familial cases have been linked to germline mutations in BRCA1 and BRCA2 genes, though other high penetrance susceptibility genes have also been identified through genomic testing advances. Optimal surgical treatment for these patients, who are of a younger age, has several challenges as it usually involves aggressive therapeutic and risk reducing interventions. At the same time, the therapeutic armamentarium for BRCA1/2 mutation carriers apart from platinum salts, has been enriched with the addition of poly-ADP ribose polymerase (PARP) inhibitors with promising outcomes. In this review we provide a succinct and comprehensive overview of the surgical and systemic treatment options for patients with BRCA1/2 mutation related breast cancer and an update on the most recent systemic treatment advances. |
| Databáze: | OpenAIRE |
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