Ventricular arrhythmia and sudden cardiac death in young Leonbergers
| Autor: | K. Hagner, Kati Dillard, Hannes Lohi, Marjo K. Hytönen, Julia E. Niskanen, Maria Wiberg, Marjukka Anttila |
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| Přispěvatelé: | Equine and Small Animal Medicine, Maria Wiberg / Principal Investigator, University Management, Hannes Tapani Lohi / Principal Investigator, Department of Medical and Clinical Genetics, Veterinary Biosciences, Medicum, Veterinary Genetics, Veterinary Pathology and Parasitology, Helsinki One Health (HOH), Haartman Institute (-2014) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
TROPONIN-I Physiology M-MODE ECHOCARDIOGRAPHY Disease 030204 cardiovascular system & hematology 413 Veterinary science AMBULATORY ELECTROCARDIOGRAPHY RECOMMENDATIONS Sudden cardiac death 0403 veterinary science Electrocardiography 0302 clinical medicine ANIMAL-MODEL Troponin I Dog Diseases Family history High prevalence Inheritance medicine.diagnostic_test DTILAED CARDIOMYOPATHY 04 agricultural and veterinary sciences ASSOCIATION 3. Good health Pedigree cardiovascular system Cardiology HEART Clinical evaluation Arrhythmia medicine.medical_specialty 040301 veterinary sciences DOBERMAN-PINSCHERS Physical examination 03 medical and health sciences Dogs Internal medicine medicine Animals cardiovascular diseases Necropsy arrhytmia General Veterinary business.industry Arrhythmias Cardiac medicine.disease DILATED CARDIOMYOPATHY PROLONGATION Death Sudden Cardiac Electrocardiography Ambulatory business Holter monitoring |
| Popis: | To describe unexpected sudden cardiac death (SCD) in young Leonbergers (3 years) and to review the circumstances before death and necropsy findings; to prospectively evaluate the presence of possible arrhythmias in young Leonbergers; and to examine pedigrees for determining potential modes of inheritance.Postmortem evaluations included 21 Leonbergers. Clinical evaluation consisted of 46 apparently healthy Leonbergers with and without a close family history of SCD.Necropsy reports were reviewed retrospectively. Prospective clinical evaluation included physical examination, 5-min electrocardiogram, 24-h Holter, echocardiography, and laboratory tests. Pedigree data were examined for mode of inheritance.Based on necropsy reports, SCD occurred at a median age of 12 months (range, 2.0-32.0 months) without any previous clinical signs and usually in rest. No evidence of structural cardiac disease was found; arrhythmia-related death was suspected. Clinical evaluation and 24-h Holter showed ventricular arrhythmia (VA) in 14 apparently healthy Leonbergers (median age, 18 months; range, 12-42 months). Severity of VA varied from infrequent couplets/triplets to frequent complexity (couplets, triplets, nonsustained ventricular tachycardias,VTs) characterized by polymorphology. During follow-up, two dogs with polymorphic VT died. Although breed specificity and high prevalence indicate a heritable disease, based on available pedigree data, the mode of inheritance could not be determined.Sudden cardiac death in young Leonbergers is associated with malignant VA characterized by complexity and polymorphic nature. Diagnosis is based on 24-h Holter monitoring. Pedigree analysis suggests that the arrhythmia is familial. |
| Databáze: | OpenAIRE |
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