Soluble interleukin-2 receptor: elevated levels in serum and synovial fluid of patients with rheumatoid arthritis
| Autor: | A. B. Carpenter, C. H. Eisenbeis, S. H. Ip, M. C. Brown, S. Carrabis |
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| Rok vydání: | 1990 |
| Předmět: |
musculoskeletal diseases
Microbiology (medical) Interleukin 2 medicine.medical_specialty medicine.drug_class Clinical Biochemistry Arthritis Monoclonal antibody Arthritis Rheumatoid In vivo Rheumatoid Factor Internal medicine Synovial Fluid medicine Immunology and Allergy Synovial fluid Rheumatoid factor Humans Receptor Immunoassay business.industry Biochemistry (medical) Public Health Environmental and Occupational Health Receptors Interleukin-2 Hematology Middle Aged medicine.disease Medical Laboratory Technology Endocrinology Solubility Rheumatoid arthritis Joint Diseases business medicine.drug |
| Zdroj: | Journal of clinical laboratory analysis. 4(2) |
| ISSN: | 0887-8013 |
| Popis: | Soluble interleukin-2 receptor (sIL-2R) levels were quantitated in the serum and synovial fluid (SF) of patients with rheumatoid arthritis (RA) and degenerative joint disease (DJD). A sandwich immunoassay, employing two monoclonal antibodies against distinct epitopes on the IL-2R, was utilized for measurement. We found a striking elevation of sIL-2R in RA SF as compared with DJD SF (RA, 1319 +/- 135; DJD, 416 +/- 59; p less than 0.001). RA serum sIL-2R levels were also significantly elevated over DJD levels. There was no interaction between rheumatoid factor (RF) and sIL-2R. RA patients with elevated sIL-2R levels had significantly longer disease duration, higher c-reactive protein (CRP) levels in serum and SF, and higher RF levels in serum and SF. The groups were similar in regard to other laboratory variables. The presence of elevated levels of sIL-2R in RA serum and SF confirms the presence of a heightened immune reactivity and in vivo activation of lymphocytes in RA. |
| Databáze: | OpenAIRE |
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