Regulation of Cancer and Cancer-Related Genes via NAD
| Autor: | Shashi Gujar, Emma Martell, Patrick W. K. Lee, Tanveer Sharif, Barry E. Kennedy, Cathleen Dai, Mohammad Saleh Ghassemi-Rad |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Physiology DNA repair Clinical Biochemistry Biochemistry Cofactor 03 medical and health sciences chemistry.chemical_compound Neoplasms medicine Animals Humans Sirtuins Molecular Biology General Environmental Science biology Chemistry Cell growth Cancer Cell Biology Oncogenes Cell cycle medicine.disease NAD Cell biology Gene Expression Regulation Neoplastic Adenosine diphosphate 030104 developmental biology Cancer cell biology.protein General Earth and Planetary Sciences NAD+ kinase Poly(ADP-ribose) Polymerases Signal Transduction |
| Zdroj: | Antioxidantsredox signaling. 30(6) |
| ISSN: | 1557-7716 |
| Popis: | Significance: NAD+ is an essential redox cofactor in cellular metabolism and has emerged as an important regulator of a wide spectrum of disease conditions, most notably, cancers. As such, various strategies targeting NAD+ synthesis in cancers are in clinical trials. Recent Advances: Being a substrate required for the activity of various enzyme families, especially sirtuins and poly(adenosine diphosphate [ADP]-ribose) polymerases, NAD+-mediated signaling plays an important role in gene expression, calcium release, cell cycle progression, DNA repair, and cell proliferation. Many strategies exploring the potential of interfering with NAD+ metabolism to sensitize cancer cells to achieve anticancer benefits are highly promising, and are being pursued. Critical Issues: With the multifaceted roles of NAD+ in cancer, it is important to understand how cellular processes are reliant on NAD+. This review summarizes how NAD+ metabolism regulates various pathophysiological processes in cancer, and how this k... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|