Effect of fish and krill oil supplementation on glucose tolerance in rabbits with experimentally induced obesity
| Autor: | E. Vachkova, Rita Vik, Lena Burri, G. Penchev, N. Grigorova, Anton Roussenov, Anelia Milanova, Spaska Stanilova, Bodil Bjørndal, Rolf K. Berge, Boycho Bivolraski, I. P. Georgiev, Kjetil Berge, V. N. Petrov, Zhenya Ivanova, T. M. Georgieva |
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| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
Hydroxymethylglutaryl-CoA Synthase Male medicine.medical_specialty CD36 Medicine (miscellaneous) Alpha (ethology) Krill oil Fish Oils Internal medicine medicine Animals Insulin Obesity Muscle Skeletal ACACA Nutrition and Dietetics biology Carnitine O-Palmitoyltransferase Fishes Skeletal muscle Fish oil Pyruvate carboxylase Endocrinology medicine.anatomical_structure Biochemistry Gene Expression Regulation Liver Lipogenesis Dietary Supplements biology.protein Carbohydrate Metabolism Rabbits Insulin Resistance Acetyl-CoA Carboxylase Euphausiacea |
| Zdroj: | European journal of nutrition. 54(7) |
| ISSN: | 1436-6215 |
| Popis: | This study was conducted to investigate the effect of fish oil (FO) and krill oil (KO) supplementation on glucose tolerance in obese New Zealand white rabbits. The experiments were carried out with 24 male rabbits randomly divided into four groups: KO—castrated, treated with KO; FO—castrated, treated with FO; C—castrated, non-treated; NC—non-castrated, non-treated. At the end of treatment period (2 months), an intravenous glucose tolerance test (IVGTT) was performed in all rabbits. Fasting blood glucose concentrations in FO and KO animals were significantly lower than in group C. The blood glucose concentrations in FO- and KO-treated animals returned to initial values after 30 and 60 min of IVGTT, respectively. In liver, carnitine palmitoyltransferase 2 (Cpt2) and 3-hydroxy-3-methyl-glutaryl-CoA synthase 2 (Hmgcs2) genes were significantly increased in FO-fed rabbits compared with the C group. Acetyl-CoA carboxylase alpha (Acaca) expression was significantly reduced in both KO- and FO-fed rabbits. In skeletal muscle, Hmgcs2 and Cd36 were significantly higher in KO-fed rabbits compared with the C group. Acaca expression was significantly lower in KO- and FO-fed rabbits compared with the C group. The present results indicate that FO and KO supplementation decreases fasting blood glucose and improves glucose tolerance in obese New Zealand white rabbits. This could be ascribed to the ameliorated insulin sensitivity and insulin secretion and modified gene expressions of some key enzymes involved in β-oxidation and lipogenesis in liver and skeletal muscle. |
| Databáze: | OpenAIRE |
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