Platelets 3H 5-HT uptake in descendants from alcoholic patients: A potential risk factor for alcohol dependence?
| Autor: | J. Y. Benard, P. Lothion, P. Compagnon, M. Daoust, D. Ernouf, G. Narcisse |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Blood Platelets Male Serotonin medicine.medical_specialty Serotonin uptake Adolescent Serotonin transport Alcohol In Vitro Techniques Tritium General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Reference Values Risk Factors Internal medicine medicine Humans Platelet General Pharmacology Toxicology and Pharmaceutics Child Mean corpuscular volume Ethanol medicine.diagnostic_test Alcohol dependence Biological Transport General Medicine Alcoholism Endocrinology chemistry Biochemistry Female |
| Zdroj: | Life Sciences. 52:989-995 |
| ISSN: | 0024-3205 |
| Popis: | We studied platelet 3H-serotonin uptake in 32 former alcoholics, withdrawn for from 1 month to 22 years, in their descendants (21.7 +/- 1.6 years old, n = 17; 10.9 +/- 0.7 years old; n = 19), and in respective control groups, paired in age and sex. All of the alcoholics presented high 3H-serotonin uptake (Vmax = 10.88 +/- 4.23 pmoles/10(8)pl/30 sec., vs. 0.93 +/- 0.15 pmole/10(8)pl/30 sec. Their descendants also showed high platelet serotonin uptake: 3.94 +/- 1.44 pmoles/10(8)pl/30 sec., vs. 0.93 +/- 0.15 pmoles/10(8)pl/30 sec. for adult descendants, and 5.99 +/- 2.23 vs. 0.84 +/- 0.15 pmole/10(8)pl/30 sec. for young descendants. All subjects were free of alcoholisation (biological parameters studied were blood ethanol concentration, gamma glutamyl transferase and mean corpuscular volume), and dependence of former alcoholics was evaluate by using, a posteriori, the CAGE test. In descendants, 28% of the subjects have Vmax values higher than the highest of the control group. Alcohol, in vitro, (54 mM) did not affect serotonin uptake in any group. These results indicate that in descendants of alcoholics, platelet serotonin uptake is altered, without modification of sensitivity to ethanol. The genetic basis of alcohol dependence could be linked with the platelet serotonin transport. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|