Peritoneal metastases from extra-abdominal cancer - A population-based study
| Autor: | Brendan Moran, K.H. Chang, Jurgen Mulsow, Conor Shields, J.G. Solon, S. Deady, M. Flanagan, Ronan A. Cahill |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Male medicine.medical_specialty Lung Neoplasms Population Breast Neoplasms Malignancy 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Registries Lung cancer education Melanoma Peritoneal Neoplasms Aged Neoplasm Staging Aged 80 and over education.field_of_study business.industry Incidence (epidemiology) Incidence Cancer General Medicine Middle Aged medicine.disease Prognosis Cancer registry Survival Rate 030104 developmental biology 030220 oncology & carcinogenesis Surgery Female Ovarian cancer business Ireland |
| Zdroj: | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 44(11) |
| ISSN: | 1532-2157 |
| Popis: | Introduction Peritoneal metastases (PM) are predominantly seen as a manifestation of intra-abdominal malignancy such as colorectal or ovarian cancer. However, extra-abdominal primary cancer can also metastasise to the peritoneum. Population-based data on the incidence of PM from extra-abdominal cancer is lacking. This study aims to assess the patterns and survival of patients in Ireland with PM from extra-abdominal cancers. Methods The National Cancer Registry of Ireland database was interrogated to identify patients diagnosed with PM from extra-abdominal malignancy during the period 1994–2012. Patient demographics and tumour characteristics were analysed. Results 5791 patients were diagnosed with PM during the study period. Of these, 543 (9%) had an extra-abdominal primary malignancy. Breast (40.8%), lung (25.6%) and melanoma (9.3%) were the most common extra-abdominal cancers to develop PM. The majority of patients with peritoneal metastases of breast origin (75%) were diagnosed at a long interval (median interval 59.5 months; range = 1–485) from the diagnosis of the primary. The median survival from diagnosis of PM was 5.8 months compared with 22.6 months from diagnosis of stage IV disease without peritoneal involvement. Survival in patients with lung cancer and melanoma who developed PM was very poor and similar to that in patients with stage IV disease not involving the peritoneum. Conclusion This is the first population-based study to report the incidence of PM secondary to extra-abdominal malignancy. The most common primary cancers were melanoma, breast and lung cancer. Metastatic disease to the peritoneum was uniformly associated with a poor prognosis. |
| Databáze: | OpenAIRE |
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