Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry
| Autor: | B. Jégou, Antoine Rolland, Sriram Sankararaman, David Reich, Frédéric Chalmel |
|---|---|
| Přispěvatelé: | Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Department of Genetics [Boston], Harvard Medical School [Boston] (HMS), Rennes Metropole, National Institutes of Health [GM100233, 4R00GM111744], National Science Foundation [HO BCS-1032255], Institut national de la sante et de la recherche medicale (Inserm), Universite de Rennes 1, Ecole des hautes etudes en sante publique (EHESP-School of Public Health), Universite Sorbonne Paris Cite (USPC), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male germ cells Neanderthal 0302 clinical medicine Databases Genetic meiosis Developmental 10. No inequality Neanderthals Natural selection Genome Gene Expression Regulation Developmental Hominidae Genomics Human Biotechnology Evolution 1.1 Normal biological development and functioning Introgression Archaic humans Biology testis Evolution Molecular 03 medical and health sciences Databases Meiosis Genetic Underpinning research biology.animal Genetics Animals Humans Allele Selection Genetic Molecular Biology Denisovan Gene Selection Ecology Evolution Behavior and Systematics Discoveries Alleles Evolutionary Biology Genome Human genetic incompatibilities Human Genome Molecular biology.organism_classification 030104 developmental biology [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics Gene Expression Regulation Evolutionary biology Generic health relevance Biochemistry and Cell Biology archaic hominin admixture 030217 neurology & neurosurgery |
| Zdroj: | Molecular biology and evolution, vol 34, iss 8 Molecular Biology and Evolution Molecular Biology and Evolution, Oxford University Press (OUP), 2017, 34 (8), pp.1974-1980. ⟨10.1093/molbev/msx141⟩ Molecular Biology and Evolution, 2017, 34 (8), pp.1974-1980. ⟨10.1093/molbev/msx141⟩ |
| ISSN: | 0737-4038 1537-1719 |
| DOI: | 10.1093/molbev/msx141⟩ |
| Popis: | International audience; About 1–6% of the genetic ancestry of modern humans today originates from admixture with archaic humans. It has recently been shown that autosomal genomic regions with a reduced proportion of Neanderthal and Denisovan ancestries (NA and DA) are significantly enriched in genes that are more expressed in testis than in other tissues. To determine whether a cellular segregation pattern would exist, we combined maps of archaic introgression with a cross-analysis of three transcriptomic datasets deciphering the transcriptional landscape of human gonadal cell types. We reveal that the regions deficient in both NA and DA contain a significant enrichment of genes transcribed in meiotic germ cells. The interbreeding of anatomically modern humans with archaic humans may have introduced archaic-derived alleles that contributed to genetic incompatibilities affecting meiosis that were subsequently purged by natural selection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|