Differential Modulation of Cancellous and Cortical Distal Femur by Fructose and Natural Mineral-Rich Water Consumption in Ovariectomized Female Sprague Dawley Rats

Autor: Cidália Pereira, Maria João Martins, Miguel Bernardes, Cecília Durães, Inês Brandão, Nuno Silva, Emanuel Passos, Rosário Monteiro, David Guede
Přispěvatelé: Instituto de Investigação e Inovação em Saúde
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Dietary Sugars / administration & dosage
Osteoporosis
Postmenopausal / diagnostic imaging
Bone density
Dietary Sugars
Cortical bone
Bone remodeling
fructose
Rats
Sprague-Dawley
0302 clinical medicine
Bone Density
Cortical Bone / metabolism
Femur
Cortical Bone / diagnostic imaging
mineral water
Osteoporosis
Postmenopausal
bone microstructure
Bone mineral
Nutrition and Dietetics
Chemistry
Cancellous bone
Collagen Type I / blood
Osteoporosis
Postmenopausal / physiopathology
6. Clean water
medicine.anatomical_structure
cancellous bone
ovariectomy
Bone microstructure
Ovariectomized rat
Cancellous Bone / diagnostic imaging
Female
Bone Remodeling
Fructose / administration & dosage
lcsh:Nutrition. Foods and food supply
Peptides / blood
musculoskeletal diseases
medicine.medical_specialty
Medullary cavity
Ovariectomy
cortical bone
Drinking
Osteoprotegerin / blood
Cancellous Bone / physiopathology
030209 endocrinology & metabolism
lcsh:TX341-641
Fructose
Femur / metabolism
Article
Collagen Type I
Osteoporosis
Postmenopausal / prevention & control
03 medical and health sciences
Osteoprotegerin
Femur / physiopathology
Internal medicine
Bone mineral density
medicine
Animals
Biomarkers / blood
Humans
Mineral water
Femur / diagnostic imaging
Osteoporosis
Postmenopausal / blood
Mineral Waters / administration & dosage
Drinking Water
RANK Ligand
RANK Ligand / blood
X-Ray Microtomography
Disease Models
Animal
030104 developmental biology
Endocrinology
Cancellous Bone / metabolism
Drinking Water / administration & dosage
Cortical Bone / physiopathology
Mineral Waters
Peptides
bone mineral density
Biomarkers
Food Science
Zdroj: Nutrients, Vol 11, Iss 10, p 2316 (2019)
Nutrients
Volume 11
Issue 10
ISSN: 2072-6643
Popis: Bone mineral density (BMD) and microstructure depend on estrogens and diet. We assessed the impact of natural mineral-rich water ingestion on distal femur of fructose-fed estrogen-deficient female Sprague Dawley rats. Ovariectomized rats drank tap or mineral-rich waters, with or without 10%-fructose, for 10 weeks. A sham-operated group drinking tap water was included (n = 6/group). Cancellous and cortical bone compartments were analyzed by microcomputed tomography. Circulating bone metabolism markers were measured by enzyme immunoassay/enzyme-linked immunosorbent assay or multiplex bead assay. Ovariectomy significantly worsened cancellous but not cortical bone, significantly increased circulating degradation products from C-terminal telopeptides of type I collagen and receptor activator of nuclear factor-kappaB ligand (RANKL), and significantly decreased circulating osteoprotegerin and osteoprotegerin/RANKL ratio. In ovariectomized rats, in cancellous bone, significant water effect was observed for all microstructural properties, except for the degree of anisotropy, and BMD (neither a significant fructose effect nor a significant interaction between water and fructose ingestion effects were observed). In cortical bone, it was observed a significant (a) water effect for medullary volume and cortical endosteal perimeter
(b) fructose effect for cortical thickness, medullary volume, cross-sectional thickness and cortical endosteal and periosteal perimeters
and (c) interaction effect for mean eccentricity. In blood, significant fructose and interaction effects were found for osteoprotegerin (no significant water effect was seen). For the first time in ovariectomized rats, the positive modulation of cortical but not of cancellous bone by fructose ingestion and of both bone locations by natural mineral-rich water ingestion is described.
Databáze: OpenAIRE
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