Variation in the dopamine D2 receptor gene plays a key role in human pain and its modulation by transcranial magnetic stimulation
| Autor: | Antti Pertovaara, Pauliina Lindholm, Nora Hagelberg, Tanja Valmunen, Jarmo Hietala, Salla Lamusuo, Arja Virtanen, Ullamari Pesonen, Tero Taiminen, Satu K. Jääskeläinen, Heli Forssell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pain Threshold medicine.medical_specialty Genotype medicine.medical_treatment Analgesic Pain Catechol O-Methyltransferase Polymorphism Single Nucleotide Gastroenterology ta3112 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Dopamine Polymorphism (computer science) Dopamine receptor D2 Internal medicine medicine Humans Pain Management Aged Pain Measurement Receptors Dopamine D2 Middle Aged Transcranial Magnetic Stimulation ta3124 Cortex (botany) Transcranial magnetic stimulation Anesthesiology and Pain Medicine Neurology Anesthesia Neuropathic pain Female Neurology (clinical) Analgesia Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | PAIN. 155(10):2180-2187 |
| ISSN: | 0304-3959 |
| DOI: | 10.1016/j.pain.2014.08.029 |
| Popis: | We tested whether variation of the dopamine D2 receptor (DRD2) gene contributes to individual differences in thermal pain sensitivity and analgesic efficacy of repetitive transcranial magnetic stimulation (rTMS) in healthy subjects (n=29) or susceptibility to neuropathic pain in patients with neurophysiologically confirmed diagnosis (n=16). Thermal sensitivity of healthy subjects was assessed before and after navigated rTMS provided to the S1/M1 cortex. All subjects were genotyped for the DRD2 gene 957C>T and catechol-O-methyltransferase (COMT) protein Val158Met polymorphisms. In healthy subjects, 957C>T influenced both innocuous and noxious thermal detection thresholds that were lowest in 957TT homozygotes (P values from .0277 to .0462). rTMS to S1 cortex had analgesic effect only in 957TT homozygote genotype (P=.0086). In patients, prevalence of 957TT homozygote genotype was higher than in a healthy Finnish population (50% vs 27%; P=.0191). Patients with 957TT genotype reported more severe pain than patients with other genotypes (P=.0351). COMT Val158Met polymorphism was not independently associated with the studied variables. Genetic regulation of DRD2 function by 957C>T polymorphism thus seems to influence thermal and pain sensitivity, its modulation by rTMS, and susceptibility to neuropathic pain. This indicates a central role for the dopamine system and DRD2 in pain and analgesia. This may have clinical implications regarding individualized selection of patients for rTMS treatment and assessment of risks for neuropathic pain. |
| Databáze: | OpenAIRE |
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