The effects of atrial natriuretic peptide on food-reinforced conditioning in rats. Interactions with neurotransmitters
| Autor: | Gyula Telegdy, Jony Gueron, Amelia Bidzseranova, Gábor Tóth |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Phenoxybenzamine Methysergide Experimental and Cognitive Psychology Behavioral Neuroscience Atrial natriuretic peptide Internal medicine medicine Haloperidol Animals Appetitive Behavior Neurotransmitter Agents Dopaminergic Association Learning Brain Classical conditioning Bicuculline Rats Endocrinology Mental Recall Cholinergic Psychology Receptors Atrial Natriuretic Factor Reinforcement Psychology Atrial Natriuretic Factor medicine.drug |
| Zdroj: | Physiology & Behavior. 53:325-328 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/0031-9384(93)90212-x |
| Popis: | The effects of two doses of rat atrial natriuretic peptide (TANP-1-28), 200 and 500 ng, on 6-day acquisition and extinction of food-reinforced conditional learning (conditional stimulus: light) were studied in rats following administration into the lateral cerebroventricle. With the higher dose, there was a tendency for facilitated acquisition and significantly delayed extinction of the positively reinforced learning task. In order to clarify whether the effect of the peptide is obtained through the involvement of neurotransmitters, the experimental animals were pretreated with different receptor blockers in selected doses that did not influence the behavioral test. Haloperidol, atropine, phenoxybenzamine, and propranolol blocked the action of ANP on extinction of the food-reinforced conditioning, whereas naloxone, bicuculline, and methysergide were ineffective. The results suggest that ANP might be considered a modulating agent in a positively reinforced conditional learning task, and that its action might involve dopaminergic, cholinergic, and alpha- and beta-adrenergic mechanisms. |
| Databáze: | OpenAIRE |
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