Delayed hypersensitivity reactions of cancer patients to antigens on lymphoid cell lines
| Autor: | Ronald B. Herberman, Francis K. Nkrumah, Phillip O. Periman, Nejib Mourali, G. B. Cannon, I. V. Perkins, Paul H. Levine, M. B. Middleton, J. H. C. Ho |
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| Rok vydání: | 1978 |
| Předmět: |
Cancer Research
Lymphoma Cell Line Epitopes Antigen In vivo Antigens Neoplasm Neoplasms Leukocytes Medicine Potency Humans Hypersensitivity Delayed Antigens Viral business.industry Cancer Nasopharyngeal Neoplasms Intradermal Tests medicine.disease Burkitt Lymphoma Leukemia Lymphoid Oncology Nasopharyngeal carcinoma Cell culture Delayed hypersensitivity Immunology Cell Migration Inhibition business |
| Zdroj: | International journal of cancer. 22(4) |
| ISSN: | 0020-7136 |
| Popis: | Four-hundred and fifty nine cancer patients were skin tested with extracts from five lymphoid cell lines. More than 50% of patients with lymphoma had positive skin tests with the extracts prepared from the cell line derived from Burkitt's lymphoma (BL) and more than 50% of nasopharyngeal carcinoma (NPC) patients reacted to the NPC-derived cell line extracts. Although the significant association between patient diagnosis and origin of cell lines suggested that tumor-associated antigens were responsible for the pattern of delayed hyper-sensitivity, problems in standardization of antigen potency and non-specificity need to be resolved before this in vivo assay achieves its full potential. |
| Databáze: | OpenAIRE |
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