Resilience and vulnerability are dose-dependently related to neonatal stressors in mice

Autor: Alessandra Berry, Giovanni Laviola, Fernando J. Santos, Simone Macrì, Oleg Granstrem, Luciano Saso, M.V. Shumilina
Rok vydání: 2009
Předmět:
bdnf
cognitive abilities
corticosterone
early experience
long-term effects
mouse
natural antibodies
neonatal stressors
psychiatric disorders
resilience
stress
vulnerability
Male
Time Factors
Neuropsychological Tests
Hippocampus
Mice
Behavioral Neuroscience
chemistry.chemical_compound
Cognition
Endocrinology
Corticosterone
Lactation
Serotonin Plasma Membrane Transport Proteins
Brain
medicine.anatomical_structure
Corticosteroid
Female
Psychology
Glucocorticoid
medicine.drug
medicine.medical_specialty
medicine.drug_class
Offspring
Mice
Inbred Strains
Dopamine
Internal medicine
medicine
Animals
Autoantibodies
Brain-derived neurotrophic factor
Dopamine Plasma Membrane Transport Proteins
Dose-Response Relationship
Drug
Endocrine and Autonomic Systems
Brain-Derived Neurotrophic Factor
Animals
Newborn
chemistry
Serotonin
Stress
Psychological
Zdroj: Hormones and Behavior. 56:391-398
ISSN: 0018-506X
Popis: Early life experiences have been shown to adjust cognitive abilities, stress reactivity, fear responses and immune activity in adult mammals of many species. However, whereas severe stressors have been generally associated with the emergence of hypothalamic pituitary adreno-cortical (HPA)-mediated pathology, mild neonatal stressful experiences have been traditionally associated with 'positive' effects or resilience. External stressors stimulate the HPA axis to induce a corticosterone secretion in mouse dams, which, in turn is directly transmitted to the progeny through lactation. Such corticosteroid transfer may offer a unitary mechanism whereby early low corticosterone exposure may favor resilience in the offspring and high corticosterone increase vulnerability to pathology. In this study we further investigated this hypothesis by evaluating the long-term effects of a neonatal exposure to low (33 mg/l) and high (100 mg/l) doses of corticosterone during the first 10 days of life in outbred CD-1 mice through supplementation in the maternal drinking water. Offspring attentional set-shifting abilities, central neurotrophic regulation and levels of natural auto-antibodies (na-Abs) directed to serotonin (SERT) and dopamine (DAT) transporters were assessed in adulthood. While low levels of neonatal corticosterone improved adult cognitive abilities and increased na-Abs levels directed to SERT, high doses of neonatal corticosterone reduced hippocampal BDNF levels and na-Abs directed to DAT. These findings confirm and extend our previous findings, supporting the view that both adaptive plasticity and pathological outcomes in adulthood may depend on circulating neonatal corticosterone levels and that these effects follow a U-shaped profile.
Databáze: OpenAIRE
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