The Rat Model of Type 2 Diabetic Mellitus and Its Glycometabolism Characters
| Autor: | Wenzhong Zhou, Chuanzhong Ye, Guo Li, Di Zhang, Youping Liu, Sheng Zheng, Xiaoyan Xie, Min Guang, Hong-da Zhu, Min Luo, Wei Ding, Yanyun Gu, Jialin Yang, Tianhong Luo, Fanglin Zhang, Gang Chen |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Population Type 2 diabetes Streptozocin General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley Islets of Langerhans chemistry.chemical_compound Insulin resistance Internal medicine Diabetes mellitus Animals Humans Insulin Medicine education Type 1 diabetes education.field_of_study Glucose tolerance test General Veterinary Triglyceride medicine.diagnostic_test business.industry General Medicine Glucose Tolerance Test medicine.disease Rats Disease Models Animal Glucose Endocrinology Diabetes Mellitus Type 2 chemistry Animal Science and Zoology Insulin Resistance business |
| Zdroj: | Experimental Animals. 52:401-407 |
| ISSN: | 1881-7122 1341-1357 |
| DOI: | 10.1538/expanim.52.401 |
| Popis: | To develop a rat model of type 2 diabetic mellitus that simulated the common manifestation of the metabolic abnormalities and resembled the natural history of a certain type 2 diabetes in human population, male Sprague-Dawley rats (4 months old) were injected with low-dose (15 mg/kg) STZ after high fat diet (30% of calories as fat) for two months (L-STZ/2HF). The functional and histochemical changes in the pancreatic islets were examined. Insulin-glucose tolerance test, islet immunohistochemistry and other corresponding tests were performed and the data in L-STZ/2HF group were compared with that of other groups, such as the model of type 1 diabetes (given 50 mg/kg STZ) and the model of obesity (high fat diet). The body weight of rats in the group of rats given 15 mg/kg STZ after high fat diet for two months increased significantly more than that of rats in the group of rats given 50 mg/kg STZ (the model of type 1 diabetes) (595 +/- 33 g vs. 352 +/- 32 g, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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