| Autor: |
JoEllen, Welsh, Min Ji, Bak, Carmen J, Narvaez |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Trends in Molecular Medicine. 28:864-881 |
| ISSN: |
1471-4914 |
| DOI: |
10.1016/j.molmed.2022.07.002 |
| Popis: |
Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential for post-translational γ-carboxylation of a small number of proteins, including clotting factors. These modified proteins have now been implicated in diverse physiological and pathological processes including cancer. Vitamin K intake has been inversely associated with cancer incidence and mortality in observational studies. Newly discovered functions of vitamin K in cancer cells include activation of the steroid and xenobiotic receptor (SXR) and regulation of oxidative stress, apoptosis, and autophagy. We provide an update of vitamin K biology, non-canonical mechanisms of vitamin K actions, the potential functions of vitamin K-dependent proteins in cancer, and observational trials on vitamin K intake and cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect