Combined Neuroprotective Strategies Blocked Neurodegeneration and Improved Brain Function in Senescence-Accelerated Mice
| Autor: | Helena Nascimento Malerba, Arthur Antonio Ruiz Pereira, Marcela Favoretto Pierrobon, Guilherme Souza Abrao, Mariana Toricelli, Eliana Hiromi Akamine, Hudson Sousa Buck, Tania Araujo Viel |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Senescence
Aging Cognitive Neuroscience Hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry Pharmacology Neuroprotection NEUROFARMACOLOGIA Neurotrophic factors SAMP-8 Medicine senile plaques Original Research Environmental enrichment active life expectancy biology business.industry lithium carbonate Neurodegeneration Long-term potentiation medicine.disease healthy aging Synaptophysin biology.protein neuroprotection business RC321-571 Neuroscience enriched environment |
| Zdroj: | Frontiers in Aging Neuroscience Frontiers in Aging Neuroscience, Vol 13 (2021) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1663-4365 |
| Popis: | Increase in the quality of life, combined with drug strategies, has been studied as possibilities for improving memory and delaying the onset of neurodegenerative diseases. A previous study published by the group of the authors has shown that microdose lithium and enriched environment can improve memory in both mice and humans. To elucidate this relationship better, this study aimed to evaluate whether the chronic combination of these two strategies could increase healthy aging in Senescence Accelerated Mouse-Prone 8 (SAMP8). Animals were submitted to either one or both of these strategies until the age of 10 months when they were anesthetized and killed and their hippocampus was extracted. The untreated SAMP-8 group exhibited worse memory and reduced neuronal density with greater neurodegeneration and increased amyloid-β plaque density compared with the control group. Moreover, significant alterations in proteins related to long-term potentiation, such as, synaptophysin and brain-derived neurotrophic factor (BDNF), were observed in this group. The strategies used in the study maintained long-term memory, reduced anxiety, and increased neuroprotection. Both strategies were efficient in reducing neurodegeneration and increasing parameters related to memory maintenance. In many experiments, the combination of the two strategies was more effective in improving healthy aging. This study sheds light on the combination of strategies that choose to improve the quality of life and drugs with low side effects. Moreover, it opens perspectives for a new field of study for healthy aging. |
| Databáze: | OpenAIRE |
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