Enhancement of the transformed shape phenotype by microtubule inhibitors and reversal by an inhibitor combination
| Autor: | H K Plummer, C A Heckman, R Mukherjee |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Cancer Research
Paclitaxel Cell Endocytic cycle Tapering Biology Microtubules Cell Line Microtubule medicine Animals Insulin Monensin Valinomycin Cell cycle Covariance Phenotype In vitro Rats medicine.anatomical_structure Cell Transformation Neoplastic Oncology Immunology Biophysics Tetradecanoylphorbol Acetate Colchicine |
| Zdroj: | International journal of oncology. 16(4) |
| ISSN: | 1019-6439 |
| Popis: | Differences between transformed cells and their normal counterparts were defined by analyzing the cells' three-dimensional distribution of mass. Variables called factors, which explained the covariance of the real variables, were extracted from the data. We found that factors #4 (sharp, tapering projections) and #12 (rounding up), corresponded to G-protein functions. Then, the signature-type mass distribution of transformed cells was defined by factor values. Agents that caused signature-type mimicry could quantitatively shift factor values, for example, those affecting endocytic processing disproportionately reduced values of #4. Signature-type reversal was also observed and may be valuable in predicting the efficacy of chemotherapeutic agents. |
| Databáze: | OpenAIRE |
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