Elevated plasma atrial natriuretic peptide levels after occlusion of the thoracic aorta
| Autor: | Gur Ben-Ari, Allan Hackshaw, Talma Rosenthal, Azriel Perel, Eran Segal, Haim Berkenstadt, Edna Peleg |
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| Rok vydání: | 1999 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Mean arterial pressure Cardiac output Hemodynamics Aorta Thoracic Blood Pressure Critical Care and Intensive Care Medicine Norepinephrine Atrial natriuretic peptide medicine.artery Medicine Thoracic aorta Humans Infusions Intra-Arterial Pulmonary wedge pressure Aged business.industry Blood flow Middle Aged medicine.anatomical_structure Anesthesia Abdominal Neoplasms Reperfusion Injury cardiovascular system Vascular resistance Female Cardiology and Cardiovascular Medicine business Mechanoreceptors Atrial Natriuretic Factor |
| Zdroj: | Chest. 115(1) |
| ISSN: | 0012-3692 |
| Popis: | Study objective The influence of occlusion of the thoracic aorta by an intraluminal balloon on plasma atrial natriuretic peptide (ANP) levels was evaluated in humans. Methods The changes in plasma ANP and plasma norepinephrine levels, and hemodynamic parameters were measured in 10 patients under general anesthesia undergoing regional chemotherapy treatment involving the 15-min inflation and subsequent deflation of an intra-aortic balloon. Results The hemodynamic changes observed were similar to those seen during aortic clamping and declamping in patients undergoing vascular surgery. Plasma ANP levels (median ± SD) measured 1 min after inflation (146 ± 117 pg/mL) and 1 min after deflation (168 ± 189 pg/mL) of the aortic balloon were significantly higher than baseline values (83 ± 55 pg/mL), with a mean increase, respectively, of 92% and 97% (95% confidence intervals [CI], 50 to 147% and 53 to 152%). Plasma ANP levels were still elevated 30 min after deflation (121 ± 94 pg/mL), a 56% increase (95% CI, 21 to 100%), although the hemodynamic parameters had already returned to their baseline levels. There was no evidence that the hemodynamic variables were associated with changes in plasma ANP levels (all p values > 0.30). In addition, there was no evidence of an association between plasma ANP and plasma norepinephrine levels at any of the four individual sampling points (p > 0.17). Thirty minutes after deflation, however, norepinephrine levels were higher than baseline values. Conclusions The changes in plasma ANP levels after aortic occlusion and reinstitution of blood flow may be dependent on parameters other than atrial stretch and pressure. |
| Databáze: | OpenAIRE |
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