Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease
| Autor: | Abhijit Sarkar, André X. C. N. Valente, Joo Ho Shin, Yuan Gao |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
Multidisciplinary Parkinson's disease business.industry Late onset Context (language use) Computational biology Disease Bioinformatics medicine.disease Article 3. Good health 03 medical and health sciences 0302 clinical medicine medicine SNP Statistical analysis business Gene 030217 neurology & neurosurgery 030304 developmental biology Coding (social sciences) |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep00256 |
| Popis: | An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's disease is discussed in the context of a Parkinson's disease stem-cell ageing theory. |
| Databáze: | OpenAIRE |
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