Macrophage heterogeneity, phenotypes, and roles in renal fibrosis

Autor:	Qi Cao, Yiping Wang, David Harris
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Kidney Effector business.industry Mini Review fibrosis Disease medicine.disease Phenotype macrophages medicine.anatomical_structure effector Nephrology Fibrosis Immunology medicine Renal fibrosis Macrophage regulatory business Kidney disease
Zdroj:	Kidney International Supplements
ISSN:	2157-1716 2157-1724
Popis:	Macrophages (MΦ) are highly heterogeneous cells that exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease type and stage. MΦ are distributed throughout normal and diseased kidney tissue, where they have been recognized as key factors in renal fibrosis. Recent studies have identified switch of phenotype and diverse roles for MΦ in several murine models of kidney disease. In this review, we discuss macrophage heterogeneity and their involvement in renal fibrosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e960929e31757e7f333972f5794bd3 http://europepmc.org/articles/PMC4536959 Zobrazit plný text záznamu