Preparation and characterization of nano-hydroxyapatite/silk fibroin porous scaffolds
| Autor: | Juming Yao, Sijia Min, Liangjun Zhu, Lin Liu, Mingqi Wang, Jinying Liu, Yurong Cai |
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| Rok vydání: | 2008 |
| Předmět: |
Materials science
Biocompatibility Composite number Biomedical Engineering Biophysics Fibroin Biocompatible Materials Bioengineering Crystallography X-Ray Biomaterials Tissue engineering Cell Line Tumor Animals Humans Composite material Porosity Tissue Engineering fungi Temperature technology industry and agriculture Bombyx Durapatite SILK Compressive strength Nanoparticles Biocomposite Fibroins |
| Zdroj: | Journal of Biomaterials Science, Polymer Edition. 19:325-338 |
| ISSN: | 1568-5624 0920-5063 |
| DOI: | 10.1163/156856208783721010 |
| Popis: | Novel tissue engineering scaffold materials of nano-hydroxyapatite (nHA)/silk fibroin (SF) biocomposite were prepared by freeze-drying. The needle-like nHA crystals of about 10 nm in diameter by 50-80 nm in length, which were uniformly distributed in the porous nHA/SF scaffolds, were prepared by a co-precipitation method with a size. The as-prepared nHA/SF scaffolds showed good homogeneity, interconnected pores and high porosity. XRD and FT-IR analysis suggested that the silk fibroin was in beta-sheet structure, which usually provides outstanding mechanical properties for silk materials. In this work, composite scaffolds containing as high as 70% (w/w) nHA were prepared, which had excellent compressive modulus and strength, higher than the scaffolds at low nHA content level and other porous biodegradable polymeric scaffolds often considered in bone-related tissue engineering reported previously. The cell compatibility of composite scaffolds was evaluated through cell viability by MTT assay. All these results indicated that these nHA/SF scaffold materials may be a promising biomaterial for bone tissue engineering. |
| Databáze: | OpenAIRE |
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