Hepatoprotective Activity of Methanol Extract of Melastoma malabathricum Leaf in Rats
| Autor: | Zuraini Ahmad, Siti Syariah Mamat, Syafawati Shamsahal Din, Z. Zabidi, Norhafizah Mohtarrudin, Wan Noraziemah Wan Zainulddin, Ismail Na, Zainul Amiruddin Zakaria, Farhana Yahya, Farah Hidayah Kamisan, Hadijah Husain |
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| Jazyk: | angličtina |
| Předmět: |
Male
Antioxidant medicine.medical_treatment Protective Agents Rats Sprague-Dawley chemistry.chemical_compound In vivo medicine Animals Humans hepatoprotective activity methanol extract Melastoma malabathricum biology medicine.diagnostic_test Traditional medicine Dimethyl sulfoxide Plant Extracts Liver Diseases in vivo General Medicine biology.organism_classification Rats Plant Leaves Anesthesiology and Pain Medicine chemistry Phytochemical Liver Complementary and alternative medicine Melastomataceae Carbon tetrachloride Methanol leaves Liver function tests Melastomaceae Phytotherapy |
| Zdroj: | Journal of Acupuncture and Meridian Studies. (1):52-55 |
| ISSN: | 2005-2901 |
| DOI: | 10.1016/j.jams.2012.08.002 |
| Popis: | The present study aimed to determine the hepatoprotective activity of a methanol extract of Melastoma malabathricum leaves (MEMM) using two established rat models. Ten groups of rats (n=6) were given a once-daily administration of 10% dimethyl sulfoxide (negative control), 200mg/kg silymarin (positive control), or MEMM (50, 250, or 500mg/kg) for 7 days followed by induction of hepatotoxicity either using paracetamol or carbon tetrachloride. Blood samples and livers were collected for biochemical and microscopic analysis. Based on the results obtained, MEMM exhibited a significant (p |
| Databáze: | OpenAIRE |
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