Insomnia Moderates the Relationship Between Amyloid-β and Cognitive Decline in Late-Life Adults without Dementia
| Autor: | Lan Tan, Chen-Chen Tan, Xi-Peng Cao, Alzheimer’s Disease Neuroimaging Initiative, Wei Xu, Juan-Juan Zou |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Neuropsychological Tests Executive Function Cognition Neuroimaging Sleep Initiation and Maintenance Disorders mental disorders Insomnia Humans Medicine Dementia Cognitive Dysfunction Effects of sleep deprivation on cognitive performance Cognitive decline Risk factor Aged Aged 80 and over Amyloid beta-Peptides business.industry General Neuroscience Neuropsychology Brain General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology Female Geriatrics and Gerontology medicine.symptom business Clinical psychology |
| Zdroj: | Journal of Alzheimer's Disease. 81:1701-1710 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: It is suggested that not all individuals with elevated Aβ will develop dementia or cognitive impairment. Environment or lifestyle might modulate the association of amyloid pathology with cognition. Insomnia is a risk factor of cognitive disorders including Alzheimer’s disease. Objective: To investigate if insomnia moderated the relationship between amyloid-β (Aβ) and longitudinal cognitive performance in non-demented elders. Methods: A total of 385 Alzheimer’s Disease Neuroimaging Initiative participants (mean age = 73 years, 48% females) who completed 4 + neuropsychological evaluations and a [18F] florbetapir positron emission tomography scan were followed up to 8 years. Linear mixed-effects regression models were used to examine the interactions effect between insomnia and Aβ on longitudinal cognitive sores, including four domains (memory [MEM], executive function [EF], language [LAN], and visuospatial function [VS]). Results: The Aβ-positive status (A+) but not insomnia independently predicted faster cognitive decline in all domains. Furthermore, the relationship between Aβ and cognitive decline was moderated by insomnia (MEM: χ2 = 4.05, p = 0.044, EF: χ2 = 4.38, p = 0.036, LAN: χ2 = 4.56, p = 0.033, and VS: χ2 = 4.12, p = 0.042). Individuals with both elevated Aβ and insomnia experienced faster cognitive decline than those with only elevated Aβ or insomnia. Conclusion: These data reinforced the values of insomnia management in preventing dementia, possibly by interacting Aβ metabolism. Future efforts are warranted to determine whether sleep improvement will postpone the onset of dementia, specifically among populations in stages of preclinical or prodromal AD. |
| Databáze: | OpenAIRE |
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