Clostridial neurotoxins as a drug delivery vehicle targeting nervous system
| Autor: | Peng Zhang, Shuowei Cai, Nagarajan Thirunavukkarasu, Radharaman Ray, Easwaran Ravichandran, Roshan Kukreja, Bal Ram Singh, Prabhati Ray, Koyel J. Ghosal |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Nervous system
education.field_of_study Botulinum Toxins business.industry Tetanus Population Central nervous system Tetanus neurotoxin General Medicine Pharmacology medicine.disease Nervous System Biochemistry Drug treatment Drug Delivery Systems medicine.anatomical_structure Tetanus Toxin nervous system Immunization Drug delivery Animals Humans Medicine business education |
| Zdroj: | Biochimie. 92:1252-1259 |
| ISSN: | 0300-9084 |
| DOI: | 10.1016/j.biochi.2010.03.005 |
| Popis: | Several neuronal disorders require drug treatment using drug delivery systems for specific delivery of the drugs for the targeted tissues, both at the peripheral and central nervous system levels. We describe a review of information currently available on the potential use of appropriate domains of clostridial neurotoxins, tetanus and botulinum, for effective drug delivery to neuronal systems. While both tetanus and botulinum neurotoxins are capable of delivering drugs the neuronal cells, tetanus neurotoxin is limited in clinical use because of general immunization of population against tetanus. Botulinum neurotoxin which is also being used as a therapeutic reagent has strong potential for drug delivery to nervous tissues. |
| Databáze: | OpenAIRE |
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