In vitro angiographic comparison of the flow-diversion performance of five neurovascular stents
| Autor: | Andrew Pagano, Henry H. Woo, Chander Sadasivan, Ronak Dholakia, David Fiorella, Ari D Kappel, Baruch B. Lieber |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Models
Anatomic medicine.medical_specialty Iohexol Hemodynamics Contrast Media In Vitro Techniques Prosthesis Design 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Flow diverter medicine.diagnostic_test Flow diversion business.industry Intracranial Aneurysm Neurovascular bundle Aneurysm Blood Vessel Prosthesis Cerebral Angiography Fluoroscopy Angiography Printing Three-Dimensional Stents Radiology business Porosity 030217 neurology & neurosurgery Blood Flow Velocity |
| Popis: | Background and purpose Data differentiating flow diversion properties of commercially available low- and high-porosity stents are limited. This in vitro study applies angiographic analysis of intra-aneurysmal flow to compare the flow-diversion performance of five neurovascular devices in idealized sidewall and bifurcation aneurysm models. Methods Five commercial devices (Enterprise, Neuroform, LVIS, FRED, and Pipeline) were implanted in silicone sidewall and bifurcation aneurysm models under physiological average flow of blood analog fluid. High-speed angiographic images were acquired pre- and post-device implantation and contrast concentration-time curves within the aneurysm were recorded. The curves were quantified with five parameters to assess changes in contrast transport, and thus aneurysm hemodynamics, due to each device. Results Inter-device flow-diversion performance was more easily distinguished in the sidewall model than the bifurcation model. There were no obvious overall statistical trends in the bifurcation parameters but the Pipeline performed marginally better than the other devices. In the sidewall geometry, overall evidence suggests that the LVIS performed better than the Neuroform and Enterprise. The Pipeline and FRED devices were statistically superior to the three stents and Pipeline was superior to FRED in all sidewall parameters evaluated. Conclusions Based on this specific set of experiments, lower-porosity flow diverters perform significantly better in reducing intra-aneurysmal flow activity than higher-porosity stents in sidewall-type geometries. The LVIS device is potentially a better flow diverter than the Neuroform and Enterprise devices, while the Pipeline is potentially better than the FRED. |
| Databáze: | OpenAIRE |
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