Redispersible Spray-Dried Powder Containing Nanoencapsulated Curcumin: the Drying Process Does Not Affect Neuroprotection In vitro
| Autor: | Diego Fontana de Andrade, Irene Clemes Külkamp-Guerreiro, Branko Vukosavljevic, Christianne Gazzana Salbego, Juliana Bender Hoppe, Adriana Raffin Pohlmann, Silvia Stanisçuaski Guterres, Maike Windbergs, Ruy Carlos Ruver Beck |
|---|---|
| Přispěvatelé: | HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany., TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany. |
| Rok vydání: | 2019 |
| Předmět: |
powders
Male Curcumin medicine.medical_treatment Pharmaceutical Science Administration Oral 02 engineering and technology Aquatic Science In Vitro Techniques 030226 pharmacology & pharmacy Hippocampus Nanocapsules neuroinflammation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oral administration Polysaccharides Drug Discovery medicine Animals curcumin spray-drying Desiccation Particle Size Rats Wistar Ecology Evolution Behavior and Systematics Aqueous solution Ecology nanocapsules General Medicine 021001 nanoscience & nanotechnology Maltodextrin In vitro Neuroprotection chemistry Spray drying Powders 0210 nano-technology Agronomy and Crop Science Adjuvant Nuclear chemistry |
| Zdroj: | AAPS PharmSciTech United States |
| ISSN: | 1530-9932 |
| Popis: | A redispersible spray-dried formulation containing curcumin-loaded, lipid-core nanocapsules (LNC-C) was developed for oral administration. The neuroprotective activity of curcumin after the spray-drying process was evaluated in vitro. The spray-dried powder (SD-LNC-C) was produced using a drying adjuvant composed of a blend of maltodextrin and L-leucine (90:10 w/w). Acceptable process yield (~ 70%) and drug content (6.5 ± 0.2 mg g-1) were obtained. SD-LNC-C was formed by smooth, spherical-shaped particles, and confocal Raman analysis indicated the distribution of the LNC-C on the surface of the leucine/maltodextrin agglomerates. The surface of the agglomerates was formed by a combination of LNC-C and adjuvants, and laser diffraction showed that SD-LNC-C had adequate aqueous redispersion, with no loss of controlled drug release behaviour of LNC-C. The in vitro curcumin activity against the lipopolysaccharide (LPS)-induced proinflammatory response in organotypic hippocampal slice cultures was evaluated. Both formulations (LNC-C and SD-LNC-C) reduced TNF-α to similar levels. Therefore, neuroprotection of curcumin in vitro may be improved by nanoencapsulation followed by spray-drying, with no loss of this superior performance. Hence, the redispersible spray-dried powder proposed here represents a suitable approach for the development of innovative nanomedicines containing curcumin for the prevention/treatment of neurodegenerative diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink