Outcome of kidney transplantation in autosomal dominant medullary cystic kidney disease type 1
| Autor: | Stavrou, Christoforos V., Constantinou-Deltas, Constantinos D., Christofides, Tasos C., Pierides, Alkis M. |
|---|---|
| Přispěvatelé: | Christofides, Tasos C. [0000-0001-6121-0683], Constantinou-Deltas, Constantinos D. [0000-0001-5549-9169] |
| Rok vydání: | 2003 |
| Předmět: |
Graft Rejection
Male Kaplan Meier method graft survival Medullary cystic kidney disease Kidney transplantation Nephronophthisis Cause of Death postoperative complication Juvenile nephronophthisis Cyst clinical article adult Graft Survival article Age Factors Middle Aged Polycystic Kidney Autosomal Dominant Tissue Donors female priority journal Nephrology Female Adult medicine.medical_specialty Autosomal dominant medullary cystic kidney disease renal system parameters government.form_of_government disease classification living donor Risk Assessment Sampling Studies Nephropathy autosomal dominant disorder medullary sponge kidney Sex Factors male Internal medicine medicine follow up Humans controlled study cadaver donor human kidney donor intermethod comparison Retrospective Studies Transplantation business.industry medicine.disease Kidney Transplantation Survival Analysis kidney failure Surgery Cyprus treatment outcome government kidney graft rejection business Follow-Up Studies Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation Nephrol.Dial.Transplant. |
| ISSN: | 1460-2385 |
| DOI: | 10.1093/ndt/gfg196 |
| Popis: | Background. Autosomal dominant medullary cystic kidney disease (ADMCKD) is an inherited, distinct, chronic, tubulointerstitial, cystic-type nephropathy, often described together with juvenile nephronophthisis as a single disease complex (NPH-MCD). However, since the recent localization of two genes responsible for ADMCKD, namely MCKD1 and MCKD2, ADMCKD has gained independent status. Unfortunately, there appears to be a distinct lack of up-to-date information in the currently available medical literature concerning worldwide patient and graft survival after renal transplantation in ADMCKD. This report is based on all 41 transplanted patients [19 suffering from autosomal dominant medullary cystic kidney disease type 1 (ADMCKD1) and 22 from other causes] who were referred for kidney transplantation from our centre in Pafos, Cyprus between 1976 and 2000. All patients had regular follow-up examinations. This report aims to present the results of kidney transplantation of the 19 ADMCKD1 patients and to compare them with those for the 22 non-ADMCKD patients. Methods. Patient and graft survival times in both groups were recorded, analysed and compared 1 and 5 years post-transplant. Patient and graft survival times were calculated according to the Kaplan-Meier method and some descriptive statistical comparisons were based on the χ2-test. Results. The 1 year patient and graft survival rates for ADMCKD1 (group A) were 100%, while the 5 year figures were 100% and 90%, respectively. For non-ADMCKD1 patients (group B) the 1 year figures were 95% for both parameters, while the 5 year figures were 93.3% for both parameters. There were no statistically significant differences in patient and graft survival times between the two groups. Conclusions. Kidney transplantation is the treatment of choice for patients suffering from ADMCKD, with an excellent outcome and no specific complications. 18 2165 2169 Cited By :10 |
| Databáze: | OpenAIRE |
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