Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops Truncatus), an Essential Step in the Conservation of at-Risk Dolphins
| Autor: | Len Thomas, Steve Horvath, Celeste Parry, Joseph A. Zoller, Cynthia R. Smith, Theoni Photopoulou, Ryan Takeshita, Enrico Pirotta, Forrest M. Gomez, Abby M. McClain, Lori H. Schwacke, Ashley Barratclough |
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| Přispěvatelé: | University of St Andrews. School of Mathematics and Statistics, University of St Andrews. School of Biology, University of St Andrews. Statistics, University of St Andrews. Centre for Research into Ecological & Environmental Modelling, University of St Andrews. Marine Alliance for Science & Technology Scotland |
| Rok vydání: | 2021 |
| Předmět: |
Aging
bottlenose dolphin QH301-705.5 QH301 Biology NDAS QH301 anatomy_morphology Epigenetics Biology (General) health care economics and organizations chronological age GE DNA methylation epigenetics biology Bottlenose dolphin aging Population demographics Chronological age biology.organism_classification QL1-991 Evolutionary biology Age estimation Zoology GE Environmental Sciences |
| Zdroj: | Journal of Zoological and Botanical Gardens, Vol 2, Iss 30, Pp 416-420 (2021) |
| Popis: | Funding: This research was funded by SERDP grant RC20-C2-1097 awarded to Peter Tyack and Prescott Award NA20NMF4390132 awarded to Ashley Barratclough. Epigenetics, specifically DNA methylation, allows for the estimation of animal age from blood or remotely sampled skin. This multi-tissue epigenetic age estimation clock uses 110 longitudinal samples from 34 Navy bottlenose dolphins (Tursiops truncatus), identifying 195 cytosine-phosphate-guanine sites associated with chronological aging via cross-validation with one individual left out in each fold (R2 = 0.95). With a median absolute error of 2.5 years, this clock improves age estimation capacity in wild dolphins, helping conservation efforts and enabling a better understanding of population demographics Publisher PDF |
| Databáze: | OpenAIRE |
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