Dynamic cerebral autoregulation is preserved during isometric handgrip and head-down tilt in healthy volunteers
| Autor: | Maria Skytioti, Signe Søvik, Maja Elstad |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Central Nervous System
Adult Male medicine.medical_specialty Cardiac output Mean arterial pressure Ultrasonography Doppler Transcranial Physiology Blood Pressure Isometric exercise 030204 cardiovascular system & hematology Cardiovascular Physiology Autonomic Nervous System Cerebral autoregulation Head-Down Tilt Young Adult 03 medical and health sciences 0302 clinical medicine Heart Rate Isometric Contraction Physiology (medical) Internal medicine medicine Homeostasis Humans head‐down tilt Original Research Hand Strength Chemistry wavelet analysis Brain Blood flow Dynamic cerebral autoregulation Healthy Volunteers isometric handgrip Blood pressure Cerebral blood flow Cerebrovascular Circulation Cardiology Female Blood Flow Velocity 030217 neurology & neurosurgery |
| Zdroj: | Physiological Reports |
| ISSN: | 2051-817X |
| Popis: | In healthy humans, cerebral blood flow (CBF) is autoregulated against changes in arterial blood pressure. Spontaneous fluctuations in mean arterial pressure (MAP) and CBF can be used to assess cerebral autoregulation. We hypothesized that dynamic cerebral autoregulation is affected by changes in autonomic activity, MAP, and cardiac output (CO) induced by handgrip (HG), head‐down tilt (HDT), and their combination. In thirteen healthy volunteers, we recorded blood velocity by ultrasound in the internal carotid artery (ICA), HR, MAP and CO‐estimates from continuous finger blood pressure, and end‐tidal CO 2. Instantaneous ICA beat volume (ICABV, mL) and ICA blood flow (ICABF, mL/min) were calculated. Wavelet synchronization index γ (0–1) was calculated for the pairs: MAP–ICABF, CO–ICABF and HR–ICABV in the low (0.05–0.15 Hz; LF) and high (0.15–0.4 Hz; HF) frequency bands. ICABF did not change between experimental states. MAP and CO were increased during HG (+16% and +15%, respectively, P |
| Databáze: | OpenAIRE |
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