Association between RANTES polymorphisms and asthma severity among Tunisian children
| Autor: | Jihene Lachheb, Kamel Hamzaoui, Agnes Hamzaoui, Hanene Chelbi |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Hypersensitivity
Immediate Male Chemokine Allergy Tunisia Adolescent Genotype Immunology Allergic inflammation medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele Child Promoter Regions Genetic Chemokine CCL5 Asthma Polymorphism Genetic biology business.industry Haplotype Case-control study Promoter General Medicine Immunoglobulin E medicine.disease Haplotypes Case-Control Studies Child Preschool biology.protein Female business |
| Zdroj: | Human Immunology. 68:675-680 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2007.04.004 |
| Popis: | The chemokine known as RANTES (regulated upon activation, normal T cells expressed and secreted) is an important element for the chemotaxis at the site of allergic inflammation. Many studies have made an interesting link between RANTES polymorphisms and asthma, showing that the variant in the promoter region is associated with high risk of asthma and severe airway obstruction. We conducted a case-control and family study aiming at identifying the relationship between polymorphisms (-28 C/G and -403 G/A) and haplotypes in the RANTES gene with asthma and severity. The results of the case control study suggest an association between alleles level of -28 C/G and -403 G/A promoter polymorphism (p = 0.01) (p = 0.00175) and asthma. Univariate analysis of the RANTES polymorphisms show an increased prevalence of the AC and AG haplotypes in asthmatics (p = 0.014) and (p = 0.015) respectively. Our data suggest that -28 C/G and -403 G/A polymorphisms within the RANTES promoter region play an important role in asthma predisposition and in the severity of airway obstruction. |
| Databáze: | OpenAIRE |
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