Epigenetically Regulated Imprinted Genes and Foetal Programming
| Autor: | Eric B. Keverne |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Genetics
Fetus Thrifty phenotype Brain development General Neuroscience Pharmacology toxicology Brain Biology Toxicology Epigenesis Genetic Fetal Development Genomic Imprinting medicine.anatomical_structure Pregnancy Placenta embryonic structures medicine Animals Humans Female Epigenetics Genomic imprinting reproductive and urinary physiology |
| Zdroj: | Neurotoxicity Research. 18:386-392 |
| ISSN: | 1476-3524 1029-8428 |
| Popis: | Genomic imprinting is a widespread epigenetic phenomenon in mammals and many imprinted genes are expressed in the developing hypothalamus and placenta. The placenta and brain are very different structures with very different roles, but in the pregnant mother they functionally interact coordinating and ensuring the provision of nutrients, timing of parturition and priming of hypothalamus for maternal care and nurturing. This interaction has been evolutionarily fine-tuned to optimise infant survival such that when resources are poor, the mother 'informs' this condition to the foetus producing a thrifty phenotype that is adapted to survive scarce resources after birth. |
| Databáze: | OpenAIRE |
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