Comparative study of dual energy CT iodine imaging and standardized concentrations before and after chemoradiotherapy for esophageal cancer
| Autor: | Yanling Yang, Xiaomin Ge, Zhongling Wang, Yiqun Xu, Changjie Pan, Kai Yuan, Wei Liu, Lu Jiang, Jingping Yu |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research Esophageal Neoplasms Esophageal cancer chemistry.chemical_element Iodine lcsh:RC254-282 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Surgical oncology Dual energy CT Genetics medicine Humans In patient Aged business.industry Significant difference Cancer Chemoradiotherapy Middle Aged Reference Standards lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Oncology chemistry Case-Control Studies 030220 oncology & carcinogenesis Female Dual energy ct Tomography X-Ray Computed Nuclear medicine business Research Article Iodine imaging |
| Zdroj: | BMC Cancer, Vol 18, Iss 1, Pp 1-7 (2018) BMC Cancer |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-018-5058-2 |
| Popis: | Background To compare dual energy CT iodine imaging and standardized iodine concentration before and after chemoradiotherapy (CRT) for esophageal cancer and evaluate the efficacy of CRT for EC by examining DECT iodine maps and standard CT values. Methods The clinical data of 45 patients confirmed by pathology with newly diagnosed esophageal cancer who underwent concurrent CRT from February 2012 to January 2017 in our department of radiology were collected. All patients underwent dual-source dual-energy CT (DECT) before and after CRT. Normalized iodine concentration (NIC) and normalized CT (NCT) corresponding to the overall cancer lesion and its maximum cross-sectional area were observed and compared. Additionally, 30 healthy individuals were compared as control group. After treatment, the patients were divided into two groups according to RECIST1.1: treatment effective group and ineffective group. Results There were 33 patients (CR 9, PR 24) in the effective group and 12 patients (SD 12, PD 0) in the ineffective group. There was no significant difference in the NIC-A, NIC-V, NCT-A and NCT-A indexes between the effective group (B group) and the ineffective group (C group) before treatment (P > 0.05). After the treatment, the above-mentioned indexes in the effective group of patients were significantly lower than before treatment, and compared with the ineffective group, the NIC-A, NIC-V, NCT-A and NCT-V values of the effective group were significantly lower than those of ineffective group (P 0.05). Conclusion Using DECT iodine map, the changes of NIC and NIC before and after CRT in patients with esophageal cancer can evaluate the effect of CRT, and does not increase the radiation dose, so it is suitable for clinical use. |
| Databáze: | OpenAIRE |
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