Study of apoptosis-related interactions in colorectal cancer
| Autor: | Meher Rizvi, Sharad Shrivastava, Himanshu Arora, Rehana Qureshi, Mordhwaj S. Parihar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty endocrine system diseases Colon Colorectal cancer Apoptosis Cell Cycle Proteins Protein Serine-Threonine Kinases Mouse model of colorectal and intestinal cancer Biology medicine.disease_cause PLK1 Proto-Oncogene Proteins p21(ras) Pathogenesis 03 medical and health sciences 0302 clinical medicine Proto-Oncogene Proteins Internal medicine microRNA medicine Humans neoplasms Gene Cell Proliferation Mutation General Medicine medicine.disease Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology Proto-Oncogene Proteins c-bcl-2 030220 oncology & carcinogenesis KRAS Tumor Suppressor Protein p53 Colorectal Neoplasms Signal Transduction |
| Zdroj: | Tumor Biology. 37:14415-14425 |
| ISSN: | 1423-0380 1010-4283 |
| Popis: | Abnormalities in apoptotic functions contribute to the pathogenesis of colorectal cancer. In this study, molecular interactions behind the apoptotic regulation have been explored. For this purpose, enrichment analysis was performed considering microRNAs (miRNAs) that putatively target TP53 and altered during colon cancer. This revealed gene associated with both TP53 and miRNAs. Further analysis showed that a significant molecular interaction between the shortlisted candidates (TP53, miR-143, KRAS, BCL2, and PLK1) exists. Mutation study was conducted to confirm the clinical relevance of candidates. It showed that the mutation extent does not significantly alter survival in patients thus making these candidates suitable as drug targets. Overall, we showed the importance of interactions between TP53, miR-143, KRAS, BCL2, and PLK1 with respect to colorectal cancer using bioinformatics approach. |
| Databáze: | OpenAIRE |
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