New biologically active marine sesquiterpenoid and steroid from the okinawan sponge of the genus Axinyssa
| Autor: | Makoto Iwashima, Takao Yamori, Kazuo Iguchi, Ikuo Terada |
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| Rok vydání: | 2002 |
| Předmět: |
Models
Molecular Magnetic Resonance Spectroscopy Stereochemistry medicine.medical_treatment Growth inhibitory Antineoplastic Agents Alkenes Catalysis Mass Spectrometry Steroid Terpene Lethal Dose 50 Japan Genus Ergosterol Drug Discovery Chemical conversion medicine Animals Humans biology Chemistry Epidioxysterol Biological activity General Chemistry General Medicine biology.organism_classification Porifera Sponge Cell culture Steroids Hydrogenation Artemia Drug Screening Assays Antitumor Oxidation-Reduction Sesquiterpenes Human cancer |
| Zdroj: | Chemicalpharmaceutical bulletin. 50(9) |
| ISSN: | 0009-2363 |
| Popis: | A new bisabolane-type sesquiterpenoid, (E)-3-isocyanobisabolane-7,10-diene (1), and a new epidioxyergostane-type steroid, 9(11)-dehydroaxinysterol (2), were isolated from the Okinawan sponge of the genus Axinyssa. Their structures were elucidated based on the results of spectroscopic analysis and chemical conversion. Epidioxysterol 2 was found to show significant growth inhibitory effects against human cancer cell lines. |
| Databáze: | OpenAIRE |
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