Induction and Inhibition of Tumor Progression
| Autor: | Lloyd D. Winberg, Mark F. Naylor, Thomas J. Slaga, Irma B. Gimenez-Conti, Barbour S. Warren, John P. G. Volpe, Naoki Yoshimi |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Invasive Lesion Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Lesion Pathogenesis Mice Text mining medicine Animals Anticarcinogenic Agents Favorable outcome Stage (cooking) Skin Papilloma business.industry gamma-Glutamyltransferase Glutathione Tumor progression Carcinogens Cancer research medicine.symptom business Carcinogenesis Biomarkers |
| Zdroj: | Experimental Biology and Medicine. 202:9-15 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | Carcinogenesis has been demonstrated by experimental and epidemiologic studies to be a multistage process composed of three major stages, initiation, promotion, and progression (1). The progression stage of this process encompasses the changes by which a tumor develops from a contained, differentiated lesion of uncoordinated growth into a rapidly growing, invasive lesion that can spread to other areas of the body, i.e., from a benign to a malignant tumor. Progression is of great therapeutic relevance because the process involves a change from a lesion that is easily treated surgically to one requiring extensive therapy with less favorable outcome. |
| Databáze: | OpenAIRE |
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