Steering tumor progression through the transcriptional response to growth factors and stroma
| Autor: | Morris E. Feldman, Yosef Yarden |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cancer immediate early genes
Transcription Genetic EGFR Receptor tyrosine kinase Biophysics Biochemistry Article law.invention Stroma Structural Biology Epidermal growth factor law Neoplasms microRNA Genetics Animals Humans Molecular Biology Genes Immediate-Early biology Epidermal Growth Factor Cell growth Cell Biology Genes erbB-1 Phenotype Cell biology Gene Expression Regulation Neoplastic MicroRNAs Tumor progression biology.protein Suppressor Growth factors Transcription |
| Popis: | Tumor progression can be understood as a collaborative effort of mutations and growth factors, which propels cell proliferation and matrix invasion, and also enables evasion of drug-induced apoptosis. Concentrating on EGFR, we discuss downstream signaling and the initiation of transcriptional events in response to growth factors. Specifically, we portray a wave-like program, which initiates by rapid disappearance of two-dozen microRNAs, followed by an abrupt rise of immediate early genes (IEGs), relatively short transcripts encoding transcriptional regulators. Concurrent with the fall of IEGs, some 30–60 min after stimulation, a larger group, the delayed early genes, is up-regulated and its own fall overlaps the rise of the final wave of late response genes. This late wave persists and determines long-term phenotype acquisition, such as invasiveness. Key regulatory steps in the orderly response to growth factors provide a trove of potential oncogenes and tumor suppressors. |
| Databáze: | OpenAIRE |
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