Release of Antral and Duodenal Gastrin in Response to an Intestinal Meal
| Autor: | Rayford Pl, Stanislaw J. Konturek, Hugo V. Villar, James C. Thompson, Llanos Ol |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Duodenum digestive system Eating Dogs Internal medicine Gastrins Pyloric Antrum medicine Animals Antrum Gastrin Intestinal phase Meal business.industry digestive oral and skin physiology Hydrogen-Ion Concentration digestive system diseases Endocrinology medicine.anatomical_structure Surgery G cell Peptides business Perfusion hormones hormone substitutes and hormone antagonists Research Article Hormone |
| Zdroj: | Annals of Surgery. 186:614-618 |
| ISSN: | 0003-4932 |
| DOI: | 10.1097/00000658-197711000-00012 |
| Popis: | In dogs prepared with isolated, innervated antral pouches, intraduodenal perfusion with liver extract at pH 7, with the atrum buffered at pH 7, resulted in a significant release of gastrin selectively from the antrum and from the duodenum. Acidification of the meal to pH 1 abolished both antral and duodenal gastrin release, whereas acidification of the antrum abolished only the antral gastrin response. After antrectomy, liver extract at pH 7 caused a diminished but significant release of duodenal gastrin. These studies provide evidence that an intestinal meal may release (in addition to a specific intestinal phase hormone) gastrin from the intestine, and from antrum, by means of a pH-sensitive mechanism which may involve a humoral agent (enterobombesin?) from the small bowel. |
| Databáze: | OpenAIRE |
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