Polymorphisms of Homologous Recombination RAD51, RAD51B, XRCC2, and XRCC3 Genes and the Risk of Prostate Cancer
| Autor: | Andrzej Wasilewski, Milena Skowrońska, Magdalena Bryś, Wanda M. Krajewska, Ewa Forma, Ewelina Wiśnik, Waldemar Różański, Maria Nowacka-Zawisza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Cancer Research Article Subject DNA repair RAD51 Single-nucleotide polymorphism Biology Polymerase Chain Reaction Polymorphism Single Nucleotide Pathology and Forensic Medicine XRCC2 Prostate cancer Gene Frequency XRCC3 Risk Factors medicine Humans Genetic Predisposition to Disease Homologous Recombination Gene Alleles RC254-282 Aged Aged 80 and over Genetics QH573-671 Prostatic Neoplasms Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cell Biology General Medicine Middle Aged medicine.disease DNA-Binding Proteins Genetic Loci Molecular Medicine Rad51 Recombinase Homologous recombination Cytology Polymorphism Restriction Fragment Length Research Article |
| Zdroj: | Analytical Cellular Pathology, Vol 2015 (2015) Analytical Cellular Pathology (Amsterdam) |
| ISSN: | 2210-7177 |
| DOI: | 10.1155/2015/828646 |
| Popis: | Genetic polymorphisms in DNA repair genes may induce individual variations in DNA repair capacity, which may in turn contribute to the risk of cancer developing. Homologous recombination repair (HRR) plays a critical role in maintaining chromosomal integrity and protecting against carcinogenic factors. The aim of the present study was to evaluate the relationship between prostate cancer risk and the presence of single nucleotide polymorphisms (SNPs) in the genes involved in HRR, that is,RAD51(rs1801320 and rs1801321),RAD51B(rs10483813 and rs3784099),XRCC2(rs3218536), andXRCC3(rs861539). Polymorphisms were analyzed by PCR-RFLP and Real-Time PCR in 101 patients with prostate adenocarcinoma and 216 age- and sex-matched controls. A significant relationship was detected between theRAD51gene rs1801320 polymorphism and increased prostate cancer risk. Our results indicate that theRAD51gene rs1801320 polymorphism may contribute to prostate cancer susceptibility in Poland. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|