Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI
| Autor: | Ramon Diaz-Arrastia, Thomas W. McAllister, Joel H. Kramer, Brandon Foreman, Alex B. Valadka, Dana Pisică, Sureyya Dikmen, Randall Merchant, Adam R. Ferguson, C. Dirk Keene, Raquel C. Gardner, Xiaoying Sun, Geoffrey T. Manley, Arthur W. Toga, Yelena G. Bodien, John D. Corrigan, Andrew I R Maas, Joseph T. Giacino, Christopher J. Madden, Pratik Mukherjee, Florence Noel, Claudia S. Robertson, Amber Nolan, Ross Zafonte, Murray B. Stein, Hester F. Lingsma, Nancy R. Temkin, Natalie Kreitzer, Opeolu Adeoye, J. Claude Hemphill, Rao P. Gullapalli, Kim Boase, Jan Verheyden, Luis Gonzalez, Laura B. Ngwenya, Christopher J. Lindsell, Miri Rabinowitz, Michael McCrea, Gillian Hotz, Jonathan Rosand, Shankar P. Gopinath, Harvey S. Levin, David M. Schnyer, Neeraj Badjatia, Ann-Christine Duhaime, Esther L. Yuh, Angelle M. Sander, Sabrina R Taylor, Étienne Gaudette, Eva M. Palacios, Gabriella Satris, Alastair J. Martin, David O. Okonkwo, Seth A. Seabury, Joan Machamer, Karen Crawford, Amy J. Markowitz, Richard G. Ellenbogen, V. Ramana Feeser, Lindsay D. Nelson, Mark Harris, Daniel P. Perl, Mary J. Vassar, Sonia Jain |
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| Přispěvatelé: | Ragauskas, Arminas, Rocka, Saulius, Tamosuitis, Tomas, Vilcinis, Rimantas, American Medical Association, Yuh, E. L., Jain, S., Sun, X., Pisica, D., Harris, M. H., Taylor, S. R., Markowitz, A. J., Mukherjee, P., Verheyden, J., Giacino, J. T., Levin, H. S., Mccrea, M., Stein, M. B., Temkin, N. R., Diaz-Arrastia, R., Robertson, C. S., Lingsma, H. F., Okonkwo, D. O., Maas, A. I. R., Manley, G. T., Adeoye, O., Badjatia, N., Boase, K., Bodien, Y., Corrigan, J. D., Crawford, K., Dikmen, S., Duhaime, A. -C., Ellenbogen, R., Feeser, V. R., Ferguson, A. R., Foreman, B., Gardner, R., Gaudette, E., Gonzalez, L., Gopinath, S., Gullapalli, R., Hemphill, J. C., Hotz, G., Keene, C. D., Kramer, J., Kreitzer, N., Lindsell, C., Machamer, J., Madden, C., Martin, A., Mcallister, T., Merchant, R., Nelson, L., Ngwenya, L. B., Noel, F., Nolan, A., Palacios, E., Perl, D., Rabinowitz, M., Rosand, J., Sander, A., Satris, G., Schnyer, D., Seabury, S., Toga, A., Valadka, A., Vassar, M., Zafonte R., (TRACK-TBI Investigators for the CENTER-TBI Investigators), Beretta, L., Section Neuropsychology, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: FPN NPPP I, Yuh, E, Jain, S, Sun, X, Pisica, D, Harris, M, Taylor, S, Markowitz, A, Mukherjee, P, Verheyden, J, Giacino, J, Levin, H, Mccrea, M, Stein, M, Temkin, N, Diaz-Arrastia, R, Robertson, C, Lingsma, H, Okonkwo, D, Maas, A, Manley, G, Adeoye, O, Badjatia, N, Boase, K, Bodien, Y, Corrigan, J, Crawford, K, Dikmen, S, Duhaime, A, Ellenbogen, R, Feeser, V, Ferguson, A, Foreman, B, Gardner, R, Gaudette, E, Gonzalez, L, Gopinath, S, Gullapalli, R, Hemphill, J, Hotz, G, Keene, C, Kramer, J, Kreitzer, N, Lindsell, C, Machamer, J, Madden, C, Martin, A, Mcallister, T, Merchant, R, Nelson, L, Ngwenya, L, Noel, F, Nolan, A, Palacios, E, Perl, D, Rabinowitz, M, Rosand, J, Sander, A, Satris, G, Schnyer, D, Seabury, S, Toga, A, Valadka, A, Vassar, M, Zafonte, R, Citerio, G, Public Health, Neurosurgery, Molecular Neuroscience and Ageing Research (MOLAR), TRACK-TBI Investigators for the CENTER-TBI Investigators |
| Rok vydání: | 2021 |
| Předmět: |
Male
validity Neurology Neurologi common data elements ethnic disparities Cohort Studies 0302 clinical medicine Tomography Original Investigation screening and diagnosis nrecovery Injuries and accidents RECOVERY Middle Aged Prognosis 3. Good health X-Ray Computed Detection classification 030220 oncology & carcinogenesis TRACK-TBI Investigators for the CENTER-TBI Investigators Biomedical Imaging Female Cognitive Sciences Radiology Intracranial Hemorrhages Comments Human 4.2 Evaluation of markers and technologies Adult concussio medicine.medical_specialty Subarachnoid hemorrhage Physical Injury - Accidents and Adverse Effects Prognosi Traumatic brain injury Clinical Sciences Traumatic Brain Injury (TBI) CONCUSSION Head trauma scale models 03 medical and health sciences Epidural hematoma Hematoma Clinical Research medicine Online First Humans Brain Concussion Traumatic Head and Spine Injury Intracranial Hemorrhage Aged Neurology & Neurosurgery business.industry Research Glasgow Coma Scale Neurosciences prediction Petechial rash Recovery of Function medicine.disease Brain Disorders Good Health and Well Being identification Human medicine Neurology (clinical) Cohort Studie Tomography X-Ray Computed business 030217 neurology & neurosurgery |
| Zdroj: | JAMA neurology, vol 78, iss 9 JAMA Neurology, 78(9), 1137-1148. American Medical Association Dark, P 2021, ' Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI. ', JAMA Neurology, vol. 78, no. 9, pp. 1137-1148 . https://doi.org/10.1001/jamaneurol.2021.2120 JAMA Neurology Jama neurology, 78(9), 1137-1148. AMER MEDICAL ASSOC JAMA neurology |
| ISSN: | 2168-6149 |
| DOI: | 10.1001/jamaneurol.2021.2120 |
| Popis: | Key Points Question Are different patterns of intracranial injury on head computed tomography associated with prognosis after mild traumatic brain injury (mTBI)? Findings In this cohort study, subarachnoid hemorrhage, subdural hematoma, and contusion often co-occurred and were associated with both incomplete recovery and more severe impairment out to 12 months after injury, while intraventricular and/or petechial hemorrhage co-occurred and were associated with more severe impairment up to 12 months after injury; epidural hematoma was associated with incomplete recovery at some points but not with more severe impairment. Some intracranial hemorrhage patterns were more strongly associated with outcomes than previously validated demographic and clinical variables. Meaning In this study, different pathological features on head computed tomography carried different implications for mild traumatic brain injury prognosis to 1 year. The longitudinal, observational study aims to identify pathological computed tomography features associated with adverse outcomes after mild traumatic brain injury. Importance A head computed tomography (CT) with positive results for acute intracranial hemorrhage is the gold-standard diagnostic biomarker for acute traumatic brain injury (TBI). In moderate to severe TBI (Glasgow Coma Scale [GCS] scores 3-12), some CT features have been shown to be associated with outcomes. In mild TBI (mTBI; GCS scores 13-15), distribution and co-occurrence of pathological CT features and their prognostic importance are not well understood. Objective To identify pathological CT features associated with adverse outcomes after mTBI. Design, Setting, and Participants The longitudinal, observational Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study enrolled patients with TBI, including those 17 years and older with GCS scores of 13 to 15 who presented to emergency departments at 18 US level 1 trauma centers between February 26, 2014, and August 8, 2018, and underwent head CT imaging within 24 hours of TBI. Evaluations of CT imaging used TBI Common Data Elements. Glasgow Outcome Scale–Extended (GOSE) scores were assessed at 2 weeks and 3, 6, and 12 months postinjury. External validation of results was performed via the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Data analyses were completed from February 2020 to February 2021. Exposures Acute nonpenetrating head trauma. Main Outcomes and Measures Frequency, co-occurrence, and clustering of CT features; incomplete recovery (GOSE scores |
| Databáze: | OpenAIRE |
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