Conversion from spermatogonia to spermatocytes: Extracellular cues and downstream transcription network
| Autor: | Yi Xie, Bang-Hong Wei, Fei-Da Ni, Wan-Xi Yang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Transcription Genetic Retinoic acid Tretinoin Spermatocyte Biology 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Downregulation and upregulation SALL4 Transcription (biology) Spermatocytes Genetics medicine Animals Humans Cell Self Renewal Spermatogenesis Transcription factor Progenitor Gene Expression Regulation Developmental General Medicine Seminiferous Tubules Spermatogonia Cell biology Up-Regulation 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Bone Morphogenetic Proteins Transcription Factors |
| Zdroj: | Gene. 764 |
| ISSN: | 1879-0038 |
| Popis: | Spermatocyte (spc) formation from spermatogonia (spg) differentiation is the first step of spermatogenesis which produces prodigious spermatozoa for a lifetime. After decades of studies, several factors involved in the functioning of a mouse were discovered both inside and outside spg. Considering the peculiar expression and working pattern of each factor, this review divides the whole conversion of spg to spc into four consecutive development processes with a focus on extracellular cues and downstream transcription network in each one. Potential coordination among Dmrt1, Sohlh1/2 and BMP families mediates Ngn3 upregulation, which marks progenitor spg, with other changes. After that, retinoic acid (RA), as a master regulator, promotes A1 spg formation with its helpers and Sall4. A1-to-B spg transition is under the control of Kitl and impulsive RA signaling together with early and late transcription factors Stra8 and Dmrt6. Finally, RA and its responsive effectors conduct the entry into meiosis. The systematic transcription network from outside to inside still needs research to supplement or settle the controversials in each process. As a step further ahead, this review provides possible drug targets for infertility therapy by cross-linking humans and mouse model. |
| Databáze: | OpenAIRE |
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