Paget's disease of the breast in male with underlying invasive ductal carcinoma: A case report with review of literature
| Autor: | Razhan K. Ali, Shaban Latif, Snur Othman, Abdulwahid M. Salih, Zuhair D. Hammood, Fahmi H. Kakamad |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Paget's disease of the breast Invasive ductal carcinoma medicine.medical_specialty Axillary lymph nodes medicine.diagnostic_test business.industry medicine.medical_treatment Sentinel lymph node Case Report Paget's disease General Medicine Malignancy medicine.disease medicine.anatomical_structure Biopsy medicine Surgery Breast Radiology business Lymph node Mastectomy Areola |
| Zdroj: | Annals of Medicine and Surgery |
| ISSN: | 2049-0801 |
| DOI: | 10.1016/j.amsu.2021.103035 |
| Popis: | Introduction Paget's disease of the breast is a rare cutaneous eczema-like condition that occurs in the nipple-areolar complex of the breast. The current study aims to report a rare case of Paget's disease of the breast associated with invasive ductal carcinoma in a male breast. Case report A 54-year-old male presented with ulceration of the left nipple-areolar complex that has been progressing over the last 6 months. On examination; there was a palpable axillary lymph node. On ultrasound, a small hypoechoic heterogenous mass was seen beneath the areola (8*4 mm) with surrounding vascularity, and a few axillary lymph nodes with normal morphology and cortical thickness. The mammography revealed some points of calcification arranged in clusters. The patient underwent left side mastectomy and sentinel lymph node biopsy. The result of histopathological examination showed left side unifocal invasive ductal carcinoma. Discussion There are two main theories that explain the histogenesis of Paget's disease of the breast with and without underlying malignancy: epidermotropic theory, which suggests an epidermal infiltration of the nipple with Paget cells, and transformative theory, which proposes a malignant transformation of normal glandular cells of the epidermis. Conclusion The clinical presentation of Paget's disease of the breast is characteristic and should always warn the surgeon of the possibility of underlying malignancy. Highlights • Paget's disease of the breast (or nipple) is a very rare cutaneous entity. • Paget's disease of the male breast is an extremely rare clinicopathologic condition. • Breast cancer in male is likewise very rare. |
| Databáze: | OpenAIRE |
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