The Development of Anti-Immunoglobulin Antibodies in Rhesus Monkeys Repeatedly Exposed to Schistosoma Japonicum *
| Autor: | W. G. Clutter, R Wistar, Robert M. Lewert, C Cole, K D Murrell, M C Yogore |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Schistosomiasis
Biology Antibody Specificity Virology medicine Animals Helminths Strain (chemistry) Schistosoma japonicum Hemagglutination Inhibition Tests medicine.disease biology.organism_classification Macaca mulatta Antibodies Anti-Idiotypic Immunoglobulin A Infectious Diseases Immunoglobulin M Immunization Immunoglobulin G Antibody Formation biology.protein Macaca Schistosoma Parasitology Rabbits Antibody |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 24:632-637 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.1975.24.632 |
| Popis: | The development of anti-immunoglobulin (Ig) antibodies in rhesus monkeys repeatedly exposed to Schistosoma japonicum cercariae was studied. Anti-Ig developed in all 8 monkeys exposed 5 times to cercariae of the Formosan strain, while none of 4 monkeys exposed once to the Philippine strain developed such antibodies in the same period. All monkeys developing anti-Ig had specificities for IgA, 6 of 8 for IgM and IgG, and 7 of 8 for rabbit Ig. The persistence of anti-Ig was greatly extended in the monkeys exposed initially to the Formosan strain and then challenged with the Philippine strain. A single monkey exposed once to the Philippine strain developed anti-IgA and anti-rabbit Ig 85 weeks post-infection. No relationship between host reaction to trapped eggs and the development of anti-Ig was discerned. The results suggest that immunization protocols designed for humans be carefully examined for their potential immunopathological side effects. |
| Databáze: | OpenAIRE |
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