The immunological role and long life-span of small lymphocytes
| Autor: | P.H. Fitzgerald |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Chromosome Aberrations
Statistics and Probability General Immunology and Microbiology Life span Applied Mathematics Chromosome Chromosome Disorders General Medicine Biology General Biochemistry Genetics and Molecular Biology Immunity In vivo Modeling and Simulation Antibody Formation Immunology biology.protein Humans Lymphocytes Antibody General Agricultural and Biological Sciences Antibody formation |
| Zdroj: | Journal of Theoretical Biology. 6:13-25 |
| ISSN: | 0022-5193 |
| DOI: | 10.1016/0022-5193(64)90063-3 |
| Popis: | From the persistence for many years of unstable, and a wide range of stable, chromosome abnormalities in the dividing cells of human leucocyte cultures, it is hypothesized that some of these cells which are believed to be small lymphocytes, have a dormant life-span which may last for several years in vivo . It is further hypothesized that these long-lived small lymphocytes are immunologically ‘committed’ and that they are an important basis of long-term immunity. The existence of such cells lessens the need for a genetic basis for stored antibody information, which can be carried adequately by a form of limited inheritance. |
| Databáze: | OpenAIRE |
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