Increased Fibroblast Elastase Activity in Acquired Cutis laxa
| Autor: | Janine Wechsler, J. Revuz, A. Cosnes, Anne Bouloc, G. Godeau, Jacques Zeller |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Systemic disease Urticaria Biopsy Dermatology Cutis Laxa Pathogenesis medicine Humans Fibroblast Skin Pancreatic Elastase integumentary system business.industry Elastase Histology Fibroblasts Elastic Tissue medicine.disease medicine.anatomical_structure Female Acquired cutis laxa business Cutis laxa Rare disease |
| Zdroj: | Dermatology. 198:346-350 |
| ISSN: | 1421-9832 1018-8665 |
| Popis: | Background: Acquired cutis laxa is a rare disease characterized by sagging skin, premature wrinkling and reduced skin elasticity. Observation: We report a 21-year-old woman, who presented with acquired cutis laxa on the face and the ear lobes. Urticarial papules had preceded for 6 years. There was no systemic involvement. Skin specimens were obtained from lax skin and urticarial papules, and from healthy controls. Histology showed only few perivascular lymphocytes in lax ear skin and a dense inflammatory infiltrate in urticarial skin. In both biopsies elastic fibres were decreased as demonstrated by computerized morphometric analyses. Elastase activities of fibroblasts in culture were evaluated. There was a 2- to 3-fold increase in elastase activity in urticarial skin fibroblasts, contrasting with a normal elastase activity in lax ear skin. Conclusion: Our findings suggest that the inflammatory cells could play a significant role in the destruction of elastic fibres. |
| Databáze: | OpenAIRE |
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