Sub-chronic indomethacin treatment and its effect on the male reproductive system of albino rats: possible protective role of black tea extract
| Autor: | Gavishiddappa A. Hadimani, Kusal K Das, Ishwar B. Bagoji, Saeed M Yendigeri |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Physiology Indomethacin Arthritis Motility 010501 environmental sciences Genitalia Male Protective Agents 01 natural sciences 03 medical and health sciences Internal medicine Drug Discovery Testis medicine Animals Testosterone Rats Wistar Spermatogenesis Sperm motility 0105 earth and related environmental sciences Pharmacology Sperm Count Tea business.industry Plant Extracts General Medicine Organ Size Luteinizing Hormone medicine.disease Sperm Spermatozoa Rats 030104 developmental biology Endocrinology Sperm Motility Histopathology Follicle Stimulating Hormone business Hormone |
| Zdroj: | Journal of basic and clinical physiology and pharmacology. 28(3) |
| ISSN: | 2191-0286 |
| Popis: | Background:Indomethacin is commonly used as a nonsteroidal anti-inflammatory drug (NSAID) to treat inflammation, arthritis and joint pains. Unfortunately, it has a wide range of adverse effects on the physiological system, including gonads. This study aimed to assess possible beneficial effects of black tea extract (BTE) against indomethacin-induced alteration of gonadal hormone levels in male rats.Methods:Adult male rats were divided into Group I (control), Group II (indomethacin, 5 mg/kg body weight [bwt.]; i.p., 21 days), Group III (BTE, 2.5 g tea leaf/dL of water, i.e. 2.5% of aqueous BTE, orally, 21 days) and Group IV (indomethacin+BTE, 21 days). Sperm count and motility, serum luteinising hormone (LH), follicle-stimulating hormone (FSH) and testosterone, along with histopathology of testes were studied. One-way ANOVA, followed by post-hoc t-test were conducted.Results:Indomethacin-treated rats showed significant decrease in testicular weight, sperm count, sperm motility, serum gonadotropins and testosterone concentrations. Histopathology of the testes showed tortuous and distorted seminiferous tubules, marked thickening of the tubular basement membrane, reduced spermatogenesis process (>30%) and marked decrease in the number of interstitial cells of Leydig in indomethacin-treated rats. Interestingly, rats supplemented with BTE showed remarkable improvements in testicular weight gain, sperm count and motility, serum gonadotropins and testosterone concentrations, along with testicular histopathology.Conclusions:The results suggest that BTE might have potential ameliorative effects against sub-chronic indomethacin-induced alteration of gonadal hormone levels in male albino rats. |
| Databáze: | OpenAIRE |
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