[3H]Imipramine binding in idiopathic pain syndromes. Basal values and changes after treatment with antidepressants
| Autor: | P. Plenge, Heimo L Nilsson, Göran Eberhard, Ulf Sundequist, E. T. Mellerup, L. von Knorring |
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| Rok vydání: | 1989 |
| Předmět: |
Blood Platelets
Imipramine medicine.medical_specialty Clomipramine Pain In Vitro Techniques 3h imipramine binding Basal (phylogenetics) Double-Blind Method Internal medicine medicine Humans Pain Management Platelet Maprotiline Pain syndrome business.industry Cell Membrane Antidepressive Agents Psychogenic pain Anesthesiology and Pain Medicine Endocrinology Neurology Neurology (clinical) business medicine.drug |
| Zdroj: | Pain. 38:261-267 |
| ISSN: | 0304-3959 |
| DOI: | 10.1016/0304-3959(89)90211-x |
| Popis: | The binding affinity (Bmax, Kd) of [3H]imipramine to platelet membranes was investigated in 43 patients with a diagnosis of idiopathic pain syndrome. Measurements were carried out prior to and after 6 weeks' treatment with the antidepressants clomipramine or maprotiline (randomized double-blind trial). Before treatment the Bmax was 11% lower (1109 +/- 237 fmol/mg protein) compared to historical control subjects (n = 21, 1240 +/- 390) and comparable to patients with psychogenic pain with affective symptoms (n = 62, 1110 +/- 360) previously measured at the same laboratory. The Kd was 0.5 +/- 0.3 nM comparable to the Kd of the controls (0.6 +/- 0.2). After 6 weeks of treatment the clomipramine group (n = 11) had significantly lower Bmax = 208.5 +/- 286 (P less than 0.001). In the maprotiline-treated patients (n = 18) the Bmax values (1221 +/- 258) tended to increase towards the values of the controls but without statistical significance. No significant statistical correlation was found between initial Bmax values and clinical outcome. |
| Databáze: | OpenAIRE |
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