The effects of humic water on endothelial cells under hyperglycemic conditions: inflammation-associated parameters
| Autor: | Katarzyna Szot, Jacek Chojnowski, Danuta Rość, Irena Ponikowska, Natallia Veryho, Małgorzata Michalska, Krzysztof Góralczyk |
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| Rok vydání: | 2018 |
| Předmět: |
Environmental Engineering
010504 meteorology & atmospheric sciences Endothelium Endothelial cells Inflammation 010501 environmental sciences Pharmacology 01 natural sciences Umbilical vein Proinflammatory cytokine HUVEC Geochemistry and Petrology Diabetes mellitus medicine Human Umbilical Vein Endothelial Cells Environmental Chemistry Humans Endothelial dysfunction Interleukin 6 Humic Substances 0105 earth and related environmental sciences General Environmental Science Water Science and Technology Cell Proliferation Original Paper biology Chemistry Interleukin-6 Tumor Necrosis Factor-alpha General Medicine medicine.disease Culture Media medicine.anatomical_structure Glucose Hyperglycemia biology.protein Tumor necrosis factor alpha Poland medicine.symptom Humic water |
| Zdroj: | Environmental Geochemistry and Health |
| ISSN: | 1573-2983 |
| Popis: | Humic waters (HW) are globally unique, deep underground, dark-brown waters containing humic acids, and they present numerous therapeutic activities including anti-inflammatory. In the present study, we use HW from source in Poland. Diabetes has become an epidemic and is a risk factor of cardiovascular diseases. Hyperglycemia in diabetes is responsible for damaging of the endothelium and increases inflammation on the surface of the vascular lining. The inflammatory process in diabetes is associated with the secretion of inflammatory cytokines by endothelial cells, e.g., tumor necrosis factor alpha (TNFα) and interleukin 6 (IL-6), and with the reduction of cell proliferation. In the study, we used cultures of endothelial cells (HUVEC line—human umbilical vein endothelial cells) with the addition 30 mM/L of glucose in the culture medium which imitated the conditions of uncontrolled diabetes. The addition of HW in the proper volume to the culture medium causes reduction of inflammation by significant decrease in inflammatory cytokines such as TNFα and IL-6 and also leads to enhancement of the cell proliferation. It appears that the adverse effects of hyperglycemia on vascular endothelial cells may be corrected by addition of humic water. The above promising results of in vitro tests provide an opportunity to the possible use of humic water in the supportive treatment of endothelial dysfunction disorders in diabetes. However, this issue requires further clinical research. |
| Databáze: | OpenAIRE |
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